Evidence map›Paper›PMID 30573748›Full record

Trial reportScientific reports2018

Induction of Human T-cell and Cytokine Responses Following Vaccination with a Novel Influenza Vaccine.

David A G Skibinski, Leigh Ann Jones, Yuan O Zhu, Lin Wu Xue, Bijin Au, Bernett Lee, Ahmad Nazri Mohamed Naim, Audrey Lee, Nivashini Kaliaperumal, Jenny G H Low and 11 more

Open access · goldAbstract readClinical Trial, Phase IMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Virus-like particle vaccinology, from bench to bedside.Cellular & molecular immunology · 2022
    Review
  6. Article
  7. Article
  8. Long Term Immune Response Produced by the SputnikV Vaccine.International journal of molecular sciences · 2021
    Article
  9. Article
  10. Advancements in protein nanoparticle vaccine platforms to combat infectious disease.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2021
    Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 9 institutions in 3 countries.

David A G SkibinskiInstitute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos Bldg, Singapore, 138673, Singapore.
Leigh Ann JonesInstitute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos Bldg, Singapore, 138673, Singapore.
Yuan O ZhuGenome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.
Lin Wu XueInstitute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos Bldg, Singapore, 138673, Singapore.
Bijin AuInstitute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos Bldg, Singapore, 138673, Singapore.ORCID http://orcid.org/0000-0002-3670-4670
Bernett LeeSingapore Immunology Network (SIgN), 8A Biomedical Grove, Immunos Bldg, Singapore, 138648, Singapore.
Ahmad Nazri Mohamed NaimGenome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.
Audrey LeeInstitute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos Bldg, Singapore, 138673, Singapore.
Nivashini KaliaperumalInstitute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos Bldg, Singapore, 138673, Singapore.
Jenny G H LowSingHealth Investigational Medicine Unit, Singapore General Hospital, Block 7, Outram Rd., Singapore, 169610, Singapore.
Lawrence S LeeClinical Trials Research Unit, Changi General Hospital, 2 Simei St. 3, Singapore, 529889, Singapore.
Michael PoidingerSingapore Immunology Network (SIgN), 8A Biomedical Grove, Immunos Bldg, Singapore, 138648, Singapore.
Philippe SaudanCytos Biotechnology AG, Wagistr. 25, Zürich-Schlieren, CH-8952, Switzerland.
Martin BachmannInselspital, RIA, Immunologie, Sahlihaus 2, CH-3010, Bern, Switzerland.
Eng Eong OoiDuke-NUS Medical School, Program in Emerging Infectious Diseases, 8 College Rd., Singapore, 169857, Singapore.
Brendon J HansonDSO National Laboratories, Bio-Defense Therapeutics Lab, 27 Medical Drive, Singapore, 117510, Singapore.
Veronica Novotny-DiermayrD3 (Drug Discovery and Development), 31 Biopolis Way, #01-02a Nanos, Singapore, 138669, Singapore.
Alex MatterD3 (Drug Discovery and Development), 31 Biopolis Way, #01-02a Nanos, Singapore, 138669, Singapore.
Anna-Marie FairhurstSingapore Immunology Network (SIgN), 8A Biomedical Grove, Immunos Bldg, Singapore, 138648, Singapore.ORCID http://orcid.org/0000-0002-8950-6192
Martin L HibberdGenome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.
John E ConnollyInstitute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos Bldg, Singapore, 138673, Singapore. jeconnolly@imcb.a-star.edu.sg.
Agency for Science, Technology and Research · SGInstitute of Molecular and Cell Biology · SGSingapore Immunology Network · SGExperimental Drug Development Centre · SGDSO National Laboratories · SGDuke-NUS Medical School · SGNational University of Singapore · SGSingHealth · SGUniversity Hospital of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cell mediated immunity plays a vital role in defense against influenza infection in humans. Less is known about the role of vaccine-induced cell mediated immunity and the cytokine responses elicited. We measured CD4

Indexed as

AdultAntibody FormationCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell ProliferationCohort StudiesCytokinesFemaleHumansImmunity, CellularInfluenza, HumanInfluenza VaccinesLymphocyte ActivationMaleMiddle AgedVaccinationCytokinesInfluenza Vaccines

Identifiers

PMID30573748
PMCPMC6301966
OpenAlexW2904208278

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.