Observational studyDiabetes care2019
Impact of Early Diabetic Ketoacidosis on the Developing Brain.
Observational study in Diabetes care, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01753934 (Diabetic Ketoacidosis and Its Impact on Neurocognition), which is not on this map. Cited by 69 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Diabetic Ketoacidosis and Its Impact on Neurocognition
Who cites it
69 citing papers in PubMed, 2 syntheses or guidelines pooled it, 129 citations in OpenAlex.
- Cognitive skills in children and adolescents with type 1 diabetes: a scoping review and meta-analysis.BMJ open diabetes research & care · 2026Pooled it
- Pooled it
- Cognitive function following diabetic ketoacidosis in young children with type 1 diabetes.Endocrinology, diabetes & metabolism · 2023Trial
- Effects of Fluid Rehydration Strategy on Correction of Acidosis and Electrolyte Abnormalities in Children With Diabetic Ketoacidosis.Diabetes care · 2021Trial
- Cognitive performance declines in older adults with type 1 diabetes: results from 32 years of follow-up in the DCCT and EDIC Study.The lancet. Diabetes & endocrinology · 2021Trial
- Cognitive Function Following Diabetic Ketoacidosis in Children With New-Onset or Previously Diagnosed Type 1 Diabetes.Diabetes care · 2020Trial
- Distinct attentional profiles associated with diabetic ketoacidosis and hypoglycemia in pediatric type 1 diabetes: MOXO-CPT assessment.Endocrine · 2026Article
- Association of Real-Time Glucose Levels and Cognitive Performance in Children with Type 1 Diabetes: A Cross-Sectional Study.Journal of clinical medicine · 2026Article
- International consensus guidance for general population screening for islet autoantibodies to diagnose early-stage type 1 diabetes: a nominal group technique process.Diabetologia · 2026Article
- Reducing Diabetic Ketoacidosis in Pediatric Type 1 Diabetes: The Impact of Screening Programs and Early Disease-Modifying Treatment.Journal of clinical medicine · 2026Review
- Time to resolution of diabetic ketoacidosis in children with type 1 diabetes: a survival analysis of clinical predictors.BMC endocrine disorders · 2026Article
- An international consensus on screening and monitoring early-stage type 1 diabetes: A roadmap to European implementation.Diabetes, obesity & metabolism · 2026Review
- Ketosis Home Management in Pediatric Type 1 Diabetes in Germany: Mismatch Between Subjective Self-Ratings and Objectively Assessed Competence in Preventing Diabetic Ketoacidosis.Children (Basel, Switzerland) · 2026Article
- Protection through early knowledge: clinical onset of type 1 diabetes in children and adolescents with and without early T1D detection programmes.BMC pediatrics · 2026Article
- The Impact of Diabetes on Brain Health in Childhood.Biomedicines · 2026Review
- Clinical Aspects and Molecular Mechanisms of Cognitive Dysfunction in Children and Adolescents with Type 1 Diabetes.Children (Basel, Switzerland) · 2026Review
- Inflammatory profile of diabetic ketoacidosis in children with type 1 diabetes.BMJ open diabetes research & care · 2026Article
- Psychological Impact of Screening for Risk of Type 1 Diabetes: an Update.Current diabetes reports · 2025Review
- Establishing Screening Programs for Presymptomatic Type 1 Diabetes: Practical Guidance for Diabetes Care Providers.The Journal of clinical endocrinology and metabolism · 2025Article
- Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 5 institutions in 1 country.
Funding
Abstract
objectiveThis study examined whether a history of diabetic ketoacidosis (DKA) is associated with changes in longitudinal cognitive and brain development in young children with type 1 diabetes. RESEARCH DESIGN AND
methodsCognitive and brain imaging data were analyzed from 144 children with type 1 diabetes, ages 4 to <10 years, who participated in an observational study of the Diabetes Research in Children Network (DirecNet). Participants were grouped according to history of DKA severity (none/mild or moderate/severe). Each participant had unsedated MRI scans and cognitive testing at baseline and 18 months.
resultsIn 48 of 51 subjects, the DKA event occurred at the time of onset, at an average of 2.9 years before study entry. The moderate/severe DKA group gained more total and regional white and gray matter volume over the observed 18 months compared with the none/mild group. When matched by age at time of enrollment and average HbA
conclusionsA single episode of moderate/severe DKA in young children at diagnosis is associated with lower cognitive scores and altered brain growth. Further studies are needed to assess whether earlier diagnosis of type 1 diabetes and prevention of DKA may reduce the long-term effect of ketoacidosis on the developing brain.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.