Evidence map›Paper›PMID 30573635›Full record

ArticleThe Journal of general physiology2019

Recovery of left ventricular function following in vivo reexpression of cardiac myosin binding protein C.

Jasmine Giles, Jitandrakumar R Patel, Adam Miller, Elizabeth Iverson, Daniel Fitzsimons, Richard L Moss

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of general physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

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  10. Spatial and Functional Distribution ofCirculation. Genomic and precision medicine · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jasmine GilesDepartment of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI.
Jitandrakumar R PatelDepartment of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI.
Adam MillerDepartment of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI.
Elizabeth IversonDepartment of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI.
Daniel FitzsimonsDepartment of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI.
Richard L MossDepartment of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI rlmoss@wisc.edu.ORCID 0000-0002-8515-7132
University of Wisconsin–Madison · US

Funding

My-BP-C Modulation of Cardiac ContractionR37HL082900 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI MOSS, RICHARD L · 2006 to 2015
$6.0M
Mechanism of regulation of cardiac contraction by phosphorylation of myosin binding protein CR01HL139883 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI CRAIG, ROGER W, RALPHE, JOHN CARTER · 2018 to 2021
$2.7M
Murine 3D Engineered Tissue Model of Human MYBPC3 MutationsR01HL107367 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI RALPHE, JOHN CARTER · 2011 to 2015
$1.8M
NHLBI NIH HHS R01 HL107367NHLBI NIH HHS R01 HL139883NHLBI NIH HHS R37 HL082900
6 · The paper itself

Abstract

The loss of cardiac myosin binding protein C (cMyBP-C) results in left ventricular dilation, cardiac hypertrophy, and impaired ventricular function in both constitutive and conditional cMyBP-C knockout (

Indexed as

AnimalsCardiac MyosinsCardiomyopathy, HypertrophicCarrier ProteinsDiastoleDoxycyclineMiceMice, KnockoutMice, TransgenicMyocardial ContractionMyocardiumMyosin Binding Protein CPhenotypeSarcomeresSystoleVentricular Function, LeftCardiac MyosinsCarrier ProteinsDoxycyclineMyosin Binding Protein C

Identifiers

PMID30573635
PMCPMC6314388
OpenAlexW2905664919

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.