ArticleScience (New York, N.Y.)2019
Concise total syntheses of (-)-jorunnamycin A and (-)-jorumycin enabled by asymmetric catalysis.
Article in Science (New York, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Total synthesis of pyridine-containing natural product Lycodine as well as its dimers and derivatives.Molecular diversity · 2026Review
- Total synthesis of natural products based on hydrogenation of aromatic rings.Beilstein journal of organic chemistry · 2026Review
- Total Synthesis of Aporphine Alkaloids via Photocatalytic Oxidative Phenol Coupling and Biological Evaluation at the Serotonin 5-HTJournal of medicinal chemistry · 2025Article
- Development of CPA-Catalyzed β-Selective Reductive Amination of Cardenolides for the Synthesis and Biological Evaluation of Hydrolytically Stable Analogs.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Concise Syntheses of Lycojapomine Alkaloids Enabled by Radical Dearomatization of a Pyrrole.Journal of the American Chemical Society · 2025Article
- Azine Dearomatization in Natural Product Total Synthesis.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Review
- Streamlined modular synthesis of saframycin substructure via copper-catalyzed three-component assembly and gold-promoted 6-Beilstein journal of organic chemistry · 2025Article
- Comparative analysis of complanadine A total syntheses.Beilstein journal of organic chemistry · 2025Review
- Evolution of a Synthetic Strategy toward the Syntheses of Bis-tetrahydroisoquinoline Alkaloids.Accounts of chemical research · 2024Article
- The Versatile and StrategicChemical reviews · 2024Review
- Switchable chemoselective aryne reactions between nucleophiles and pericyclic reaction partners using either 3-methoxybenzyne or 3-silylbenzyne.Nature communications · 2024Article
- Concise Total Synthesis of Complanadine A Enabled by Pyrrole-to-Pyridine Molecular Editing.Synthesis · 2024Article
- Recent Advances in the Total Synthesis of the Tetrahydroisoquinoline Alkaloids (2002-2020).Chemical reviews · 2023Review
- Asymmetric arene hydrogenation: towards sustainability and application.Chemical Society reviews · 2023Review
- Dearomative logic in natural product total synthesis.Natural product reports · 2022Review
- Synthesis of Saturated N-Heterocycles via a Catalytic Hydrogenation Cascade.Advanced synthesis & catalysis · 2022Article
- Article
- Concise syntheses of GB22, GB13, and himgaline by cross-coupling and complete reduction.Science (New York, N.Y.) · 2022Article
- Iridium-catalyzed asymmetricChemical science · 2022Article
- Recent Advances in the Enantioselective Synthesis of Chiral Amines via Transition Metal-Catalyzed Asymmetric Hydrogenation.Chemical reviews · 2022Review
Corrections and comments
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Authors and funding
17 authors.
Funding
Abstract
The bis-tetrahydroisoquinoline (bis-THIQ) natural products have been studied intensively over the past four decades for their exceptionally potent anticancer activity, in addition to strong Gram-positive and Gram-negative antibiotic character. Synthetic strategies toward these complex polycyclic compounds have relied heavily on electrophilic aromatic chemistry, such as the Pictet-Spengler reaction, that mimics their biosynthetic pathways. Herein, we report an approach to two bis-THIQ natural products, jorunnamycin A and jorumycin, that instead harnesses the power of modern transition-metal catalysis for the three major bond-forming events and proceeds with high efficiency (15 and 16 steps, respectively). By breaking from biomimicry, this strategy allows for the preparation of a more diverse set of nonnatural analogs.
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