ArticleEMBO reports2019
A microRNA cluster in the Fragile-X region expressed during spermatogenesis targets FMR1.
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Article in EMBO reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
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24 citing papers in PubMed, 32 citations in OpenAlex.
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- Small Differences and Big Changes: The Many Variables of MicroRNA Expression and Function in the Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Study of MicroRNA Cluster Located on Chromosome X in Serum and Breast Cancer Tissue.Biochemical genetics · 2024Article
- Small noncoding RNAs and sperm nuclear basic proteins reflect the environmental impact on germ cells.Molecular medicine (Cambridge, Mass.) · 2024Article
- A cluster of X-linked miRNAs are de-repressed with age in mouse liver and target growth hormone signaling.Frontiers in aging · 2023Article
- Regulation of both transcription and RNA turnover contribute to germline specification.Nucleic acids research · 2022Article
- Uncoupling transcription and translation through miRNA-dependent poly(A) length control in haploid male germ cells.Development (Cambridge, England) · 2022Article
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- Sex-Dependent Changes of miRNA Levels in the Hippocampus of Adrenalectomized Rats Following Acute Corticosterone Administration.ACS chemical neuroscience · 2021Article
- RHOX10 drives mouse spermatogonial stem cell establishment through a transcription factor signaling cascade.Cell reports · 2021Article
- The Potential Role of miRNAs as Predictive Biomarkers in Neurodevelopmental Disorders.Journal of molecular neuroscience : MN · 2021Review
- TheProceedings of the National Academy of Sciences of the United States of America · 2021Article
- ChrXq27.3 miRNA cluster functions in cancer development.Journal of experimental & clinical cancer research : CR · 2021Review
- Expression of the chrXq27.3 miRNA cluster in recurrent ovarian clear cell carcinoma and its impact on cisplatin resistance.Oncogene · 2021Article
- PERK Signaling Controls Myoblast Differentiation by Regulating MicroRNA Networks.Frontiers in cell and developmental biology · 2021Article
- What microRNAs could tell us about the human X chromosome.Cellular and molecular life sciences : CMLS · 2020Review
- Article
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Authors and funding
13 authors at 4 institutions in 2 countries.
Madhuvanthi RamaiahDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Diego, La Jolla, CA, USA.
Kun TanDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-8567-7795
Terra-Dawn M PlankDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Diego, La Jolla, CA, USA.
Hye-Won SongDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Diego, La Jolla, CA, USA.
Jennifer N ChousalDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Diego, La Jolla, CA, USA.
Samantha JonesDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Diego, La Jolla, CA, USA.
Eleen Y ShumDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Diego, La Jolla, CA, USA.
Steven D SheridanChemical Neurobiology Laboratory, Center for Genomic Medicine, Boston, MA, USA.
Kevin J PetersonDepartment of Biological Sciences, Dartmouth College, Hanover, NH, USA.
Jörg GromollCenter for Reproductive Medicine and Andrology, University of Münster, Münster, Germany.
Stephen J HaggartyChemical Neurobiology Laboratory, Center for Genomic Medicine, Boston, MA, USA.
Heidi Cook-AndersenDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Diego, La Jolla, CA, USA.
Miles F WilkinsonDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Diego, La Jolla, CA, USA mfwilkinson@ucsd.edu.ORCID 0000-0002-6416-3058
University of California San Diego · USMassachusetts General Hospital · USDartmouth College · USUniversity of Münster · DE
Funding
UC San Diego Womens Reproductive Health Research ProgramK12HD001259 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CYNTHIA GYAMFI-BANNERMAN · 1999 to 2026
$9.1MTRAINING IN REPRODUCTIVE SCIENCEST32HD007203 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PAMELA L MELLON · 1988 to 2026
$4.8MSpermatogonial Stem Cell Establishment and RegulationR01GM119128 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TAN, KUN, WILKINSON, MILES FROME · 2016 to 2025
$3.6MMechanisms driving the transition from oocyte to embryo: The role of the mRNA decay activator ZFP36L2.R01GM124519 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI COOK-ANDERSEN, HEIDI · 2018 to 2022
$1.7MThe Role of NMD in Olfactory NeurogenesisR01GM111838 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WILKINSON, MILES FROME · 2014 to 2017
$1.6MThe Role of NMD in Pre-Implantation DevelopmentF30HD089579 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHOUSAL, JENNIFER · 2016 to 2018
$110kThe role of the nonsense mediated RNA decay pathway in regulating cell fateF32GM113487 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BRANNAN, TERRA-DAWN PLANK · 2015 to 2016
$109kNICHD NIH HHS F30 HD089579NICHD NIH HHS K12 HD001259NICHD NIH HHS T32 HD007203NIGMS NIH HHS F32 GM113487NIGMS NIH HHS R01 GM111838NIGMS NIH HHS R01 GM119128NIGMS NIH HHS R01 GM124519
Abstract
Testis-expressed X-linked genes typically evolve rapidly. Here, we report on a testis-expressed X-linked microRNA (miRNA) cluster that despite rapid alterations in sequence has retained its position in the Fragile-X region of the X chromosome in placental mammals. Surprisingly, the miRNAs encoded by this cluster (
Indexed as
Multigene FamilyRNA Interference3' Untranslated RegionsAnimalsFragile X Messenger Ribonucleoprotein 1Gene Expression RegulationHumansMaleMiceMicroRNAsRNA, MessengerSpermatogenesisTestis3' Untranslated RegionsFMR1 protein, humanFragile X Messenger Ribonucleoprotein 1MicroRNAsRNA, MessengerevolutionFMR1microRNAtestistranslation
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.