Evidence map›Paper›PMID 30573504›Full record

ArticleHaematologica2019

The thymidine dideoxynucleoside analog, alovudine, inhibits the mitochondrial DNA polymerase γ, impairs oxidative phosphorylation and promotes monocytic differentiation in acute myeloid leukemia.

Dana Yehudai, Sanduni U Liyanage, Rose Hurren, Biljana Rizoska, Mark Albertella, Marcela Gronda, Danny V Jeyaraju, Xiaoming Wang, Samir H Barghout, Neil MacLean and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Haematologica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Dana YehudaiPrincess Margaret Cancer Centre, University Health Network, ON, Canada.
Sanduni U LiyanagePrincess Margaret Cancer Centre, University Health Network, ON, Canada.
Rose HurrenPrincess Margaret Cancer Centre, University Health Network, ON, Canada.
Biljana RizoskaMedivir AB, Huddinge, Sweden.
Mark AlbertellaPrincess Margaret Cancer Centre, University Health Network, ON, Canada.
Marcela GrondaPrincess Margaret Cancer Centre, University Health Network, ON, Canada.
Danny V JeyarajuPrincess Margaret Cancer Centre, University Health Network, ON, Canada.
Xiaoming WangPrincess Margaret Cancer Centre, University Health Network, ON, Canada.
Samir H BarghoutPrincess Margaret Cancer Centre, University Health Network, ON, Canada.
Neil MacLeanPrincess Margaret Cancer Centre, University Health Network, ON, Canada.
Thirushi P SiriwardenaPrincess Margaret Cancer Centre, University Health Network, ON, Canada.
Yulia JitkovaPrincess Margaret Cancer Centre, University Health Network, ON, Canada.
Paul Targett-AdamsPrincess Margaret Cancer Centre, University Health Network, ON, Canada.
Aaron D SchimmerPrincess Margaret Cancer Centre, University Health Network, ON, Canada aaron.schimmer@uhn.ca.
Princess Margaret Cancer Centre · CAUniversity Health Network · CAMedivir (Sweden) · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mitochondrial DNA encodes 13 proteins that comprise components of the respiratory chain that maintain oxidative phosphorylation. The replication of mitochondrial DNA is performed by the sole mitochondrial DNA polymerase γ. As acute myeloid leukemia (AML) cells and stem cells have an increased reliance on oxidative phosphorylation, we sought to evaluate polymerase γ inhibitors in AML. The thymidine dideoxynucleoside analog, alovudine, is an inhibitor of polymerase γ. In AML cells, alovudine depleted mitochondrial DNA, reduced mitochondrial encoded proteins, decreased basal oxygen consumption, and decreased cell proliferation and viability. To evaluate the effects of polymerase γ inhibition with alovudine

Indexed as

AnimalsAntiviral AgentsApoptosisCell DifferentiationCell ProliferationDideoxynucleosidesDNA Polymerase gammaHumansLeukemia, Myeloid, AcuteMaleMiceMice, Inbred NODMice, SCIDMitochondriaMonocytesOxidative PhosphorylationalovudineAntiviral AgentsDideoxynucleosidesDNA Polymerase gammaPOLG protein, humanThymidine

Identifiers

PMID30573504
PMCPMC6518883
OpenAlexW2905400988

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.