Evidence map›Paper›PMID 30573466›Full record

ArticleG3 (Bethesda, Md.)2019

Identifying

Amy Huei-Yi Lee, D Patrick Bastedo, Ji-Young Youn, Timothy Lo, Maggie A Middleton, Inga Kireeva, Jee Yeon Lee, Sara Sharifpoor, Anastasia Baryshnikova, Jianfeng Zhang and 7 more

Open access · goldAbstract read
In one paragraph

Article in G3 (Bethesda, Md.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Immunodiversity of theFrontiers in plant science · 2020
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 2 countries.

Amy Huei-Yi LeeDepartment of Cell & Systems Biology, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0003-3250-3246
D Patrick BastedoDepartment of Cell & Systems Biology, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-7698-7994
Ji-Young YounThe Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.
Timothy LoDepartment of Cell & Systems Biology, University of Toronto, Toronto, Ontario, Canada.
Maggie A MiddletonCentre for the Analysis of Genome Evolution & Function, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-5577-3479
Inga KireevaCentre for the Analysis of Genome Evolution & Function, University of Toronto, Toronto, Ontario, Canada.
Jee Yeon LeeCentre for the Analysis of Genome Evolution & Function, University of Toronto, Toronto, Ontario, Canada.
Sara SharifpoorThe Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.
Anastasia BaryshnikovaLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey.
Jianfeng ZhangDepartment of Cell & Systems Biology, University of Toronto, Toronto, Ontario, Canada.
Pauline W WangCentre for the Analysis of Genome Evolution & Function, University of Toronto, Toronto, Ontario, Canada.
Sergio G PeisajovichDepartment of Cell & Systems Biology, University of Toronto, Toronto, Ontario, Canada.
Michael ConstanzoThe Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.
Brenda J AndrewsThe Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.
Charles M BooneThe Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.
Darrell DesveauxDepartment of Cell & Systems Biology, University of Toronto, Toronto, Ontario, Canada david.guttman@utoronto.ca darrell.desveaux@utoronto.ca.
David S GuttmanDepartment of Cell & Systems Biology, University of Toronto, Toronto, Ontario, Canada david.guttman@utoronto.ca darrell.desveaux@utoronto.ca.ORCID 0000-0001-8479-3869
University of Toronto · CAPrinceton University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gram-negative bacterial pathogens inject type III secreted effectors (T3SEs) directly into host cells to promote pathogen fitness by manipulating host cellular processes. Despite their crucial role in promoting virulence, relatively few T3SEs have well-characterized enzymatic activities or host targets. This is in part due to functional redundancy within pathogen T3SE repertoires as well as the promiscuity of individual T3SEs that can have multiple host targets. To overcome these challenges, we generated and characterized a collection of yeast strains stably expressing 75 T3SE constructs from the plant pathogen

Indexed as

AcetyltransferasesBacterial ProteinsKinesinsProtein BindingPseudomonas syringaeSaccharomyces cerevisiaeType III Secretion SystemsVirulence FactorsAcetyltransferasesBacterial ProteinsKinesinsType III Secretion SystemsVirulence FactorsHopZ1KinesinPathogen-host interactionsPathogenic Genetic ArrayPseudomonas syringaeType III secreted effectorYeast screen

Identifiers

PMID30573466
PMCPMC6385969
OpenAlexW2906225254

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.