Trial reportAmerican journal of preventive medicine2019
Physical Activity and Performance Impact Long-term Quality of Life in Older Adults at Risk for Major Mobility Disability.
Trial report in American journal of preventive medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
72 citing papers in PubMed, 4 syntheses or guidelines pooled it, 167 citations in OpenAlex.
- Physical inactivity in chronic airways disease: an important candidate in the treatable traits paradigm.European respiratory review : an official journal of the European Respiratory Society · 2026Pooled it
- Natural Setting Interventions to Increase Physical Activity Level in Older Adults With Intellectual Disabilities: A Systematic Review.Journal of applied research in intellectual disabilities : JARID · 2025Pooled it
- Interventions to promote mobility and quality of life in nursing homes: A systematic review.Nursing open · 2023Pooled it
- Effectiveness of Exergame Intervention on Walking in Older Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Physical therapy · 2021Pooled it
- Effects of a Physical Activity Intervention on Perceived Stress, Fatigue, and Depressive Symptoms in Older Adults: A Secondary Analysis of the LIFE Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Trial
- Cost-effectiveness of a physical activity and behaviour maintenance programme on functional mobility decline in older adults: an economic evaluation of the REACT (Retirement in Action) trial.The Lancet. Public health · 2022Trial
- Trial
- Associations of serum neurofilament light chain concentration with able life and healthy life in older adults: The Cardiovascular Health Study.Archives of gerontology and geriatrics · 2026Article
- The promise of virtual and augmented reality for optimizing community engagement in driving health equity solutions.BMC public health · 2026Article
- Lifestyle behaviors and health-related quality of life: a comparative analysis of older and non-older adults.Archives of public health = Archives belges de sante publique · 2026Article
- Association of vitamin K intake with physical function, handgrip strength, and mortality among U.S. adults: NHANES 2003-2016.Nutrition research and practice · 2026Article
- Long-term changes in health-related quality of life among Australian adults with psychological distress: a 16-year perspective.Archives of public health = Archives belges de sante publique · 2025Article
- The relationship of cytomegalovirus with physical functioning and health-related quality of life in older adults.European geriatric medicine · 2025Article
- Predicting the relationship of general self-efficacy and quality of life of the older adults with physical/mobility disabilities: a cross-sectional study in Northern Iran.BMC geriatrics · 2025Article
- The impact of slow mobility and built environment characteristics on 12.5-year all-cause mortality among older women and men: A prospective cohort study from Poland.SSM - population health · 2025Article
- Adverse effects of obesity on overall health, quality of life, and related physical health metrics: A cross-sectional and longitudinal study from the All of Us Research Program.Journal of internal medicine · 2025Article
- Staying active, staying sharp: the relationship between physical activity and health-related quality of life for people living with cognitive impairment.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025Article
- Quality of life in older patients with cancer and related unmet needs: a scoping review.Acta oncologica (Stockholm, Sweden) · 2025Article
- The relationship between spousal empowerment, quality of life, and subjective wellbeing among disabled elderly.Frontiers in psychology · 2025Article
- Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 7 institutions in 1 country.
Funding
Abstract
introductionOlder adults are a rapidly growing segment of the U.S. POPULATION: Mobility problems that lead to further disability can be addressed through physical activity interventions. Quality of life outcome results are reported from a large trial of physical activity for sedentary older adults at risk for mobility disability.
methodsData were from the Lifestyle Interventions and Independence for Elders study. This multisite RCT compared physical activity to health education among 1,635 randomly assigned sedentary older adults at risk for mobility disability in 2010-2011. Measures included demographics; comorbidity; a timed 400-meter walk; the Short Physical Performance Battery; and the Quality of Well-Being Scale (0-1.0 scale). Baseline and long-term follow-up (2.6 years) health-related quality of life data were collected as a secondary outcome. Multivariate linear regression modeling was used to examine covariates of health-related quality of life over time in 2017.
resultsThe sample had an overall mean Quality of Well-Being score of 0.613. Both groups declined in quality of life over time, but assignment to the physical activity intervention resulted in a slower decline in health-related quality of life scores (p=0.03). Intervention attendance was associated with higher health-related quality of life for both groups. Baseline characteristics including younger age, fewer comorbid conditions, non-white ethnicity, and faster 400-meter walk times were also associated with higher health-related quality of life over time.
conclusionsDeclining mobility measured by physical performance is associated with lower quality of life in sedentary older adults. Physical activity interventions can slow the decline in quality of life, and targeting specific subgroups may enhance the effects of such interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.