ArticleJournal of studies on alcohol and drugs2018
Adolescent Brain Surface Area Pre- and Post-Cannabis and Alcohol Initiation.
Article in Journal of studies on alcohol and drugs, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- The Influence of Cannabis and Nicotine Co-use on Neuromaturation: A Systematic Review of Adolescent and Young Adult Studies.Biological psychiatry · 2021Pooled it
- Adolescent substance use initiation and long-term neurobiological outcomes: insights, challenges and opportunities.Molecular psychiatry · 2024Review
- Emotion Recognition and Self-Reported Emotion Processing in Alcohol and Cannabis Co-Using Young Adults.Behavioral sciences (Basel, Switzerland) · 2024Article
- The Combined Effects of Nicotine and Cannabis on Cortical Thickness Estimates in Adolescents and Emerging Adults.Brain sciences · 2024Article
- Associations between alcohol use and sex-specific maturation of subcortical gray matter morphometry from adolescence to adulthood: Replication across two longitudinal samples.Developmental cognitive neuroscience · 2023Article
- Effects of combined use of alcohol and delta-9-tetrahydrocannibinol on working memory in Long Evans rats.Behavioural brain research · 2023Article
- Effects of combined use of alcohol and delta-9-tetrahydrocannibinol on working memory in Long Evans rats.bioRxiv : the preprint server for biology · 2023Article
- A bibliometric analysis of the cannabis and cannabinoid research literature.Journal of cannabis research · 2022Article
- Shared Genetic Etiology between Cortical Brain Morphology and Tobacco, Alcohol, and Cannabis Use.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Effects of Persistent Binge Drinking on Brain Structure in Emerging Adults: A Longitudinal Study.Frontiers in psychiatry · 2022Article
- Alcohol use and interoception - A narrative review.Progress in neuro-psychopharmacology & biological psychiatry · 2021Review
- The Effects of Alcohol and Cannabis Co-Use on Neurocognitive Function, Brain Structure, and Brain Function.Current behavioral neuroscience reports · 2021Article
- Which came first: Cannabis use or deficits in impulse control?Progress in neuro-psychopharmacology & biological psychiatry · 2021Review
- The Influence of Recreational Substance Use in TMS Research.Brain sciences · 2020Review
- Assessing the Role of Cannabis Use on Cortical Surface Structure in Adolescents and Young Adults: Exploring Gender and Aerobic Fitness as Potential Moderators.Brain sciences · 2020Article
- Adolescent Substance Use and the Brain: Behavioral, Cognitive and Neuroimaging Correlates.Frontiers in human neuroscience · 2020Article
- Cannabis and the developing brain: What does the evidence say?Birth defects research · 2019Review
- Orbitofrontal cortex volume prospectively predicts cannabis and other substance use onset in adolescents.Journal of psychopharmacology (Oxford, England) · 2019Article
- Exploring Cannabis and Alcohol Co-Use in Adolescents: A Narrative Review of the Evidence.Journal of dual diagnosisReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveChanges in gray matter volume and thickness are associated with adolescent alcohol and cannabis use, but the impact of these substances on surface area remains unclear. The present study expands on previous findings to examine the impact of alcohol and cannabis on surface area before and after use initiation.
methodScans for 69 demographically similar youth were obtained at baseline (ages 12-14 years; before substance use) and at 6-year follow-up (ages 17-21 years). Participants were classified into three groups based on substance use: alcohol use initiators (ALC, n = 23), alcohol and cannabis use initiators (ALC+CU, n = 23), and individuals with minimal substance use (<3 lifetime alcohol and 0 marijuana use episodes; CON, n = 23). For each hemisphere, group differences in surface area across time (pre- and post-substance use initiation) and significant group-by-time interactions were examined individually for 34 cortical regions using repeated measures analysis of covariance. A vertex-wise analysis assessed group differences in surface area percent change.
resultsA significant group-by-time interaction was found in three regions, bilateral medial orbitofrontal cortices and right insula. Although all regions showed decreases in surface area over time (ps < .05), a more substantial decrease was identified in the ALC group. Of note, the right medial orbitofrontal cortex survived the conservative vertex-wise analyses (p < .001), as a more substantial decrease was found in the ALC compared to the ALC+CU group in this region.
conclusionsSurface area in the medial orbitofrontal cortex may be a useful intermediate phenotype for exploring the mechanisms underlying the effects of substance use on brain development.
Indexed as
Identifiers
30573013PMC6308167W2906283400What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.