Evidence map›Paper›PMID 30572969›Full record

ArticlePsychological medicine2019

Longitudinal changes in brain activation during anticipation of monetary loss in bipolar disorder.

Anna Manelis, Richelle Stiffler, Jeanette C Lockovich, Jorge R C Almeida, Haris A Aslam, Mary L Phillips

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychological medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Prefrontal cortical activation during working memory task anticipation contributes to discrimination between bipolar and unipolar depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Anna ManelisDepartment of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-6605-5130
Richelle StifflerDepartment of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, PA, USA.
Jeanette C LockovichDepartment of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, PA, USA.
Jorge R C AlmeidaDell Medical School, The University of Texas at Austin, Austin, TX, USA.ORCID 0000-0002-1213-1986
Haris A AslamDepartment of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, PA, USA.
Mary L PhillipsDepartment of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, PA, USA.
University of Pittsburgh Medical Center · USThe University of Texas at Austin · US

Funding

Toward the identification of biomarkers of bipolar disorderR01MH076971 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PHILLIPS, MARY LOUISE · 2007 to 2011
$2.1M
Task preparation abnormality in individuals with unipolar and bipolar depressionK01MH104348 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MANELIS, ANNA · 2015 to 2018
$626k
NIMH NIH HHS K01 MH104348NIMH NIH HHS R01 MH076971
6 · The paper itself

Abstract

backgroundIndividuals with bipolar disorder (BD) show aberrant brain activation patterns during reward and loss anticipation. We examined for the first time longitudinal changes in brain activation during win and loss anticipation to identify trait markers of aberrant anticipatory processing in BD.

methodsThirty-four euthymic and depressed individuals with BD-I and 17 healthy controls (HC) were scanned using functional magnetic resonance imaging twice 6 months apart during a reward task.

resultsHC, but not individuals with BD, showed longitudinal reductions in the right lateral occipital cortex (RLOC) activation during processing of cues predicting possible money loss (p-corrected <0.05). This result was not affected by psychotropic medication, mood state or the changes in depression/mania severity between the two scans in BD. Elevated symptoms of subthreshold hypo/mania at baseline predicted more aberrant longitudinal patterns of RLOC activation explaining 12.5% of variance in individuals with BD.

conclusionsIncreased activation in occipital cortex during negative outcome anticipation may be related to elevated negative emotional arousal during anticipatory cue processing. One interpretation is that, unlike HC, individuals with BD were not able to learn at baseline that monetary losses were smaller than monetary gains and were not able to reduce emotional arousal for negative cues 6 months later. Future research in BD should examine how modulating occipital cortical activation affects learning from experience in individuals with BD.

Indexed as

Anticipation, PsychologicalAdultBipolar DisorderFemaleHumansMagnetic Resonance ImagingMaleMotivationPrefrontal CortexRewardVentral StriatumBipolar disorderfMRIlongitudinalloss anticipationoccipital cortex

Identifiers

PMID30572969
PMCPMC6663653
OpenAlexW2906298420

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.