Evidence map›Paper›PMID 30572947›Full record

ArticleStem cell research & therapy2018

Remission of HIV-related naïve and high-risk Burkitt's lymphoma treated by autologous stem cell transplantation plus cART.

Haiyan Min, Jianwei Yang, Sanbin Wang, Pengfei Tao, Yuqin Song, Xiaopei Wang, Huiqin Li, Xinping Yang, Xingqi Dong, Fu-Sheng Wang and 3 more

Abstract read
In one paragraph

Article in Stem cell research & therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Human Immunodeficiency Virus Related Non-Hodgkin's Lymphoma.Blood and lymphatic cancer : targets and therapy · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Haiyan MinYunnan Provincial Hospital of Infectious Diseases, Kunming, 650301, China.
Jianwei YangThe Third People's Hospital of Yunnan Province, Kunming, 650011, China.
Sanbin WangKunming General Hospital of Chengdu Military Region, Kunming, 650118, China.
Pengfei TaoYunnan Provincial Hospital of Infectious Diseases, Kunming, 650301, China.
Yuqin SongBeijing Cancer Hospital, Peking University, Beijing, 100142, China.
Xiaopei WangBeijing Cancer Hospital, Peking University, Beijing, 100142, China.
Huiqin LiYunnan Provincial Hospital of Infectious Diseases, Kunming, 650301, China.
Xinping YangYunnan Provincial Hospital of Infectious Diseases, Kunming, 650301, China.
Xingqi DongYunnan Provincial Hospital of Infectious Diseases, Kunming, 650301, China.
Fu-Sheng WangTreatment and Research Centre for Infectious Disease, Beijing 302 Hospital, Beijing, 100039, China.
Ming ShiTreatment and Research Centre for Infectious Disease, Beijing 302 Hospital, Beijing, 100039, China.
Xicheng WangYunnan Provincial Hospital of Infectious Diseases, Kunming, 650301, China. wxch62597@foxmail.com.
Ruonan XuTreatment and Research Centre for Infectious Disease, Beijing 302 Hospital, Beijing, 100039, China. xuruonan2004@aliyun.com.

Funding

The Capital Characteristic Clinic Project Z161100000516011
6 · The paper itself

Abstract

A 27-year-old male with HIV-associated naïve and high-risk Burkitt's lymphoma sequentially received short-term, high-dose non-myeloablative chemotherapy and autologous CD34-positive stem cell transfusion in the setting of combined antiretroviral therapy (cART). Prompt hematopoietic recovery was observed after 2 weeks and clinical remission from Burkitt's lymphoma within approximately 30 months after transplantation. The HIV RNA load was inhibited persistently, and drug resistance was not observed. The CD4+ T cell count approached 323 cells/μL in a recent follow-up study. This case suggests that the use of intensive non-myeloablative chemotherapy with transplantation, combined with antiretroviral therapy, in HIV-related naive and high-risk Burkitt's lymphoma was tolerated and safe.

Indexed as

AdultAnti-Retroviral AgentsBurkitt LymphomaCombined Modality TherapyHematopoietic Stem Cell TransplantationHIV InfectionsHumansMaleTransplantation, AutologousTransplantation ConditioningAnti-Retroviral AgentsAntiretroviral therapyAutologous stem cell transplantationBurkitt’s lymphomaCD4+THIVNaïve

Identifiers

PMID30572947
PMCPMC6302511

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.