ArticleVeterinary research2018
Gut colonization by a novel Clostridium species is associated with the onset of epizootic rabbit enteropathy.
Article in Veterinary research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 33 citations in OpenAlex.
- Lifestyle associates with unique resistome and microbiome signatures in children.BMC microbiology · 2026Article
- Isolation, Characterization, and Epizootiology of Clostridioides cuniculi from Immunodeficient Mice with Enteric Disease.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025Article
- Effect of rabbit gastrointestinal stasis (RGIS) on the fecal microbiota of pet rabbits (Oryctolagus cuniculus).PloS one · 2025Article
- Article
- Lactobacillus supports Clostridiales to restrict gut colonization by multidrug-resistant Enterobacteriaceae.Nature communications · 2022Article
- Pathogen profiling of Australian rabbits by metatranscriptomic sequencing.Transboundary and emerging diseases · 2022Article
- Effect of Feeding Insoluble Fiber on the Microbiota and Metabolites of the Caecum and Feces of Rabbits Recovering from Epizootic Rabbit Enteropathy Relative to Non-Infected Rabbits.Pathogens (Basel, Switzerland) · 2022Article
- Antibiotic removal does not affect cecal microbiota balance and productive parameters in LP robust rabbit line.Frontiers in veterinary science · 2022Article
- An Investigation of the Relationship betweenPathogens (Basel, Switzerland) · 2021Article
- Metataxonomic and Histopathological Study of Rabbit Epizootic Enteropathy in Mexico.Animals : an open access journal from MDPI · 2020Article
- Nectarivorous Bird Emphysematous Ingluvitis (NBEI): A Novel Disease in Loriinae Birds Associated WithFrontiers in veterinary science · 2020Article
- Rabbit Enteropathies on Commercial Farms in the Iberian Peninsula: Etiological Agents Identified in 2018-2019.Animals : an open access journal from MDPI · 2019Article
- Faecal microbiota and functional capacity associated with weaning weight in meat rabbits.Microbial biotechnology · 2019Article
- Myxomatosis and Rabbit Haemorrhagic Disease: A 30-Year Study of the Occurrence on Commercial Farms in Spain.Animals : an open access journal from MDPI · 2019Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
Epizootic rabbit enteropathy (ERE) represents one of the most devastating diseases affecting rabbit farms. Previous studies showing transmissibility of disease symptoms through oral inoculation of intestinal contents from sick animals suggested a bacterial infectious origin for ERE. However, no etiological agent has been identified yet. On the other hand, ERE is associated with major changes in intestinal microbial communities, pinpointing dysbiosis as an alternative cause for the disease. To better understand the role of intestinal bacteria in ERE development, we have performed a prospective longitudinal study in which intestinal samples collected from the same animals before, during and after disease onset were analyzed using high-throughput sequencing. Changes in hundreds of bacterial groups were detected after the initiation of ERE. In contrast, before ERE onset, the microbiota from rabbits that developed ERE did not differ from those that remained healthy. Notably, an expansion of a single novel Clostridium species (Clostridium cuniculi) was detected the day of ERE onset. C. cuniculi encodes several putative toxins and it is phylogenetically related to the two well-characterized pathogens C. botulinum and C. perfringens. Our results are consistent with a bacterial infectious origin of ERE and discard dysbiosis as the initial trigger of the disease. Although experimental validation is required, results derived from sequencing analysis, propose a key role of C. cuniculi in ERE initiation.
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