Evidence map›Paper›PMID 30572827›Full record

ArticleBMC pregnancy and childbirth2018

Maternal type 1collagen N-terminal telopeptide levels in severe hyperemesis gravidarum.

E Sahin, Y Madendag, M Eraslan Sahin, A T Tayyar, I Col Madendag, M Gozukucuk, C Karakukcu, G Acmaz, I I Muderris

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pregnancy and childbirth, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02862496 (Urine N-telopeptide, Serum Vit D, Parathormone and Calcium Levels in Hyperemesis Gravidarum), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02862496 unknown statusnot on this map

Urine N-telopeptide, Serum Vit D, Parathormone and Calcium Levels in Hyperemesis Gravidarum

Typeobservational_patient_registrySponsorKayseri Education and Research HospitalRan2016 to 2016Enrolled60ConditionsHyperemesis Gravidarum
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

E SahinDepartment of Obstetrics and Gynecology, Health Sciences University, Sivas Sarkısla Government Hospital, Sivas, Turkey. erdemsahin07@hotmail.com.
Y MadendagDepartment of Obstetrics and Gynecology, Health Sciences University, Kayseri Education and Research Hospital, Kayseri, Turkey.
M Eraslan SahinDepartment of Obstetrics and Gynecology, Health Sciences University, Sivas Sarkısla Government Hospital, Sivas, Turkey.ORCID http://orcid.org/0000-0001-6484-9132
A T TayyarDepartment of Obstetrics and Gynecology, Health Sciences University, Zeynep Kamil Maternity and Children's Training and Research Hospital, İstanbul, Turkey.
I Col MadendagDepartment of Obstetrics and Gynecology, Health Sciences University, Kayseri Education and Research Hospital, Kayseri, Turkey.
M GozukucukDepartment of Obstetrics and Gynecology, Health Sciences University, Kayseri Education and Research Hospital, Kayseri, Turkey.
C KarakukcuDepartment of Biochemistry Clinic, Health Sciences University, Kayseri Education and Research Hospital, Kayseri, Turkey.
G AcmazDepartment of Obstetrics and Gynecology, Health Sciences University, Kayseri Education and Research Hospital, Kayseri, Turkey.
I I MuderrisDepartment of Obstetrics and Gynecology, Erciyes University Faculty of Medicine, Kayseri, Turkey.
Kayseri Eğitim ve Araştırma Hastanesi · TRSivas State Hospital · TRErciyes University · TRZeynep Kamil Hospital · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNausea and vomiting occur 50-90% during the first trimester of pregnancy. However, patients with hyperemesis gravidarum (HG) may be hospitalized at an incidence rate of 0.8-2% before the 20th week of gestational age. The symptoms generally start during the 5-6th gestational weeks, reaching the highest degree during the 9th week, and decline after the 16-20th weeks of gestation. Clinical findings are proportional to the severity of the disease and severe HG is characterized with dehydration, electrolyte imbalance, and nutritional deficiency as a result of vomiting.

methodsThe study population consisted of two groups of pregnant volunteers at 5-12 weeks of gestation: a severe HG group and a control group. The HG severity was scored using the Pregnancy-Unique Quantification of Emesis (and nausea) (PUQE).The serum levels of the maternal Ca, parathyroid hormone (PTH), Na, K, blood urea nitrogen(BUN), creatinine, vitamin D(25OHD3), and the maternal urine NTx levels were compared between the groups.

resultsIn total, 40 volunteers were enrolled in this study: 20 healthy pregnant volunteers and 20 with severe HG. There were no statistically significant differences between the maternal characteristics. The first trimester weight loss of ≥5 kg was significantly higher in the severe HG group (p < 0.001), while the control group had a significantly higher sunlight exposure ratio than the severe HG group (p = 0.021). The urine NTx levels were significantly higher in the severe HG group (39.22 ± 11.68NTx/Cre) than in the control group(32.89 ± 8.33NTx/Cre) (p = 0.028).The serum Ca, PTH, Na, K, BUN, and creatinine levels were similar between the groups (p = 0.738, p = 0.886, p = 0.841, p = 0.957, p = 0.892, and p = 0.824, respectively). In the severe HG group, the serum 25OHD

conclusionsThe data from this study indicated that severe HG is associated with increased urine NTx levels. However, large-scale studies are required to understand the clinical significance of this finding, as well as the long-term consequences of elevated urine NTx levels and the underlying mechanisms.

trial registrationNCT02862496 Date of registration: 21/07/2016.

Indexed as

Hyperemesis GravidarumMalnutritionWater-Electrolyte ImbalanceWeight LossAdultBody Mass IndexCollagen Type ICorrelation of DataFemaleHumansPeptidesPregnancyPregnancy Trimester, FirstResearch DesignResearch SubjectsSeverity of Illness IndexCollagen Type Icollagen type I trimeric cross-linked peptidePeptidesHyperemesis gravidarumUrine NtxUrine type 1 collagen N-terminal telopeptideVitamin D deficiency

Identifiers

PMID30572827
PMCPMC6302387
OpenAlexW2906252277

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.