ArticleBMC infectious diseases2018
Risk of death after first-time blood stream infection in incident dialysis patients with specific consideration on vascular access and comorbidity.
Article in BMC infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05248620 (Prophylactic Antibiotic Treatment in End Stage Kidney Disease and Central Venous Catheter as Hemodialysis Vascular Access), which is not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prophylactic Antibiotic Treatment in End Stage Kidney Disease and Central Venous Catheter as Hemodialysis Vascular Access
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Peritoneal dialysis versus haemodialysis for people commencing dialysis.The Cochrane database of systematic reviews · 2024Pooled it
- Plasma concentration of orally administered amoxicillin and clindamycin in patients receiving haemodialysis.The Journal of antimicrobial chemotherapy · 2023Trial
- Catheter-related bloodstream infections in hemodialysis: microbiology, antimicrobial resistance, complications and predictors of mortality.BMC infectious diseases · 2026Article
- Latent profile analysis of knowledge, attitude and practice of hospital infection prevention and control among haemodialysis nurses in Sichuan, China: a multicenter study.Frontiers in public health · 2026Article
- Prognostic Factors for Mortality in Catheter-Related Bloodstream Infections Among Hemodialysis Patients: A Prospective Single-Center Study.Medicina (Kaunas, Lithuania) · 2025Article
- New-onset atrial fibrillation following arteriovenous fistula increases adverse clinical events in dialysis patients with end-stage renal disease.Frontiers in cardiovascular medicine · 2024Article
- Early identification of bloodstream infection in hemodialysis patients by machine learning.Heliyon · 2023Article
- Tunneled catheter-related bacteremia in hemodialysis patients: incidence, risk factors and outcomes. A 14-year observational study.Journal of nephrology · 2023Observational
- Eliminating financial disincentives to living kidney donation - a call to action.Frontiers in medicine · 2023Article
- Incidence and challenges in management of hemodialysis catheter-related infections.Scientific reports · 2022Article
- First-year mortality in incident dialysis patients: results of the Peridialysis study.BMC nephrology · 2022Article
- Evaluation of central venous catheter and other risk factors for mortality in chronic hemodialysis patients with COVID-19 in Brazil.International urology and nephrology · 2022Observational
- Increased vulnerability to COVID-19 in chronic kidney disease.Journal of internal medicine · 2021Article
- The application value of oXiris-endotoxin adsorption in sepsis.American journal of translational research · 2021Article
- The current and future landscape of dialysis.Nature reviews. Nephrology · 2020Review
- Article
- Risk of Complications and Survival of Patients Dialyzed with Permanent Catheters.Medicina (Kaunas, Lithuania) · 2019Article
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe mortality following blood stream infection (BSI) and risk of subsequent BSI in relation to dialysis modality, vascular access, and other potential risk factors has received relatively little attention. Consequently, we assessed these matters in a retrospective cohort study, by use of the Danish nation-wide registries.
methodsPatients more than 17 years of age, who initiated dialysis between 1.1.2010 and 1.1.2014, were grouped according to their dialysis modality and vascular access. Survival was modeled in time-dependent Cox proportional hazard analyses. Potential risk factors confined by a modified Charlson comorbidity index (MCCI), were subsequently assessed in stepwise selection models.
resultsAt baseline, 764 patients received peritoneal dialysis (PD), and 434, 479, and 782 hemodialysis (HD) patients were dialyzed by use of arteriovenous fistulas (AVFs), tunneled catheters (TCs), and non-tunneled catheters (NTCs), respectively. We identified 1069 BSIs with an overall incidence rate of 17.7 episodes per 100 person years, and 216 BSIs occurred more than one time in the same patient. HRs of post BSI mortality relative to PD were 3.20 (95% CI 1.86-5.50; p < 0.001) with NTCs; whereas no associations were found for AVF and TC. The risk of subsequent BSIs was higher with NTCs [HR 2.29 (95% CI 1.09-4.82), p = 0.030], and no significant difference was found for AVF and TC, in relation to PD. There was an increased risk of both outcomes with TC relative to AVF [death: 1.57 (95% CI 1.07-2.29, P < 0.021); BSI: 1.78 (95% CI 1.13-2.83, P < 0.014], and risk of death was reduced in patients who changed to AVF after first-time BSI. The MCCI was significantly associated with the risk of subsequent BSI and post BSI death; however, only some of the variables contained in the index were found to be significant risk predictors when analyzed in the fitted model.
conclusionsWhile NTC was the most predominant risk factor for subsequent BSI and post BSI mortality, AVF appeared protective.
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