ArticleGenetics, selection, evolution : GSE2018
A novel deletion in KRT75L4 mediates the frizzle trait in a Chinese indigenous chicken.
Article in Genetics, selection, evolution : GSE, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- A systematic review and meta-analysis of effect of mutant traits in chickens.Tropical animal health and production · 2025Pooled it
- Comparative Performance Evaluation and Genetic Potential of Frizzle and Deshi Dwarf Chicken Under Intensive Management Condition.Veterinary medicine and science · 2026Article
- A review of genetic variation underlying chicken phenotypic diversity.Poultry science · 2025Review
- - Invited Review - Challenges and constraints to the sustainability of poultry farming in China.Animal bioscience · 2025Article
- One-Step Genetic Modification by Embryonic Doral Aorta Injection of Adenoviral CRISPR/Cas9 Vector in Chicken.International journal of molecular sciences · 2024Article
- Modification of Keratin Integrations and the Associated Morphogenesis in Frizzling Chicken Feathers.Biology · 2024Article
- Enriched atlas of lncRNA and protein-coding genes for the GRCg7b chicken assembly and its functional annotation across 47 tissues.Scientific reports · 2024Article
- In-depth transcriptome profiling of Cherry Valley duck lungs exposed to chronic heat stress.Frontiers in veterinary science · 2024Article
- Dietary Canthaxanthin Supplementation Promotes the Laying Rate and Follicular Development of Huaixiang Hens.Biology · 2023Article
- Altered hair root gene expression profiles highlight calcium signaling and lipid metabolism pathways to be associated with curly hair initiation and maintenance in Mangalitza pigs.Frontiers in genetics · 2023Article
- Analysis and comparison of protein secondary structures in the rachis of avian flight feathers.PeerJ · 2022Article
- Poultry Response to Heat Stress: Its Physiological, Metabolic, and Genetic Implications on Meat Production and Quality Including Strategies to Improve Broiler Production in a Warming World.Frontiers in veterinary science · 2021Review
- Common Gene Modules Identified for Chicken Adiposity by Network Construction and Comparison.Frontiers in genetics · 2020Article
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Authors and funding
16 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundHighly diversified in morphology and structure, feathers have evolved into various forms. Frizzle feathers, which result from a developmental defect of the feather, are observed in several domestic chicken breeds. The frizzle phenotype is consistent with incomplete dominance of a major gene, but the molecular mechanisms that underlie this phenotype remain obscure. Kirin, a Chinese indigenous chicken breed that originated in the Guangdong province, is famous for its frizzle feathers. The KRT75 gene is considered as the dominant gene responsible for the frizzle trait in several chicken breeds, but this is not the case in the Kirin breed. Thus, the objective of our study was to investigate the genomic region and mutation responsible for this phenotype in this particular breed.
resultsA resource population was produced by crossing Kirin and Huaixiang chickens to produce F
conclusionsA deletion in the KRT75L4 gene is responsible for the frizzle feather phenotype in the Kirin chicken. The identification of this mutation, which causes a developmental defect of avian integument appendages, will improve our understanding of the mechanisms that are involved in feather formation.
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