ArticlePharmaceutics2018
Choline-Amino Acid Ionic Liquids as Green Functional Excipients to Enhance Drug Solubility.
Article in Pharmaceutics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The trial behind it
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Who cites it
33 citing papers in PubMed.
- Enhancement of solubility and antioxidant activity of quercetin in choline-aspartate ionic liquid: spectroscopic, volumetric and kinetic insights.BMC chemistry · 2026Article
- Taurine-based Active Pharmaceutical Ingredient Ionic Liquids Modulate the Perifollicular Microenvironment for Androgenic Alopecia Treatment.Advanced healthcare materials · 2026Article
- Ionic Liquid-Enabled Drug Delivery Systems: Benefits, Limitations, and Future Perspectives.Pharmaceutics · 2026Review
- Effect of choline-tryptophan based ionic liquid on the solubility and scavenging activity of quercetin: thermophysical and spectroscopic approach.BMC chemistry · 2025Article
- Insight into the time-dependent corrosion protection of mild steel by green ionic liquids: a combined electrochemical, surface, and computational study.RSC advances · 2025Article
- An Overview on the Role of Ionic Liquids and Deep Eutectic Solvents in Oral Pharmaceuticals.Pharmaceutics · 2025Review
- Ionic liquids and their potential use in development and improvement of drug delivery systems: evidence of their tendency to promote drug accumulation in the brain.Pharmaceutical development and technology · 2024Review
- A New 2-Aminospiropyrazolylammonium Cation with Possible Uses in the Topical Areas of Ionic Liquids.Molecules (Basel, Switzerland) · 2024Review
- Critical assessment of interactions between ct-DNA and choline-based magnetic ionic liquids: evidences of compaction.Chemical science · 2024Article
- New Ferulic Acid and Amino Acid Derivatives with Increased Cosmeceutical and Pharmaceutical Potential.Pharmaceutics · 2022Article
- Design of ionic liquids containing glucose and choline as drug carriers, finding the link between QM and MD studies.Scientific reports · 2022Article
- Simultaneously Embedding Indomethacin and Electrodeposition of Polypyrrole on Various CoCr Alloys from Ionic Liquids.Materials (Basel, Switzerland) · 2022Article
- A Computational Analysis of the Reaction of SOMolecules (Basel, Switzerland) · 2022Article
- Cuspareine as alkaloid against COVID-19 designed with ionic liquids: DFT and docking molecular approaches.Journal of photochemistry and photobiology. B, Biology · 2022Article
- Topical delivery of salicylates.Drug delivery and translational research · 2022Review
- Transdermal Permeation Assays of Curcumin Aided by CAGE-IL: In Vivo Control of Psoriasis.Pharmaceutics · 2022Article
- Antifungal Activity and Stability of Fluconazole Emulsion Containing Ionic Liquids Explained by Intermolecular Interactions.Pharmaceutics · 2022Article
- Enhancement of the Solubility and Bioavailability of Pitavastatin through a Self-Nanoemulsifying Drug Delivery System (SNEDDS).Pharmaceutics · 2022Article
- Revisiting the Physicochemical Properties and Applications of Deep Eutectic Solvents.Molecules (Basel, Switzerland) · 2022Review
- Ionic liquids as effective additives to enhance the solubility and permeation for puerarin and ferulic acid.RSC advances · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The development of effective forms to incorporate poorly soluble drugs into delivery systems remains a problem. Thus, it is important to find alternatives such as finding excipients that increase drug solubility. Ionic liquids (ILs), particularly choline-based ILs, have been studied as solubility enhancers in drug delivery systems. Nonetheless, to acknowledge this property as a functionality, it needs to be proven at non-toxic concentrations. Hence, herein two choline-amino acid ILs were studied as functional excipients by evaluating their influence on the solubility of the poorly water-soluble ferulic acid and rutin, while considering their safety. The solubility of the drugs was always higher in the presence of the ILs than in water. Ionic liquids did not affect the radical scavenging activity of the drugs or the cell viability. Moreover, stable oil-in-water (O/W) emulsions were prepared containing each drug and the ILs, allowing a significantly higher drug loading. Globally, our results suggest that choline-based ILs may act as green functional excipients, since at non-toxic concentrations they considerably improve drug solubility/loading, without influencing the antioxidant activity of the drugs, the cell viability, or the stability of the formulations.
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Registered trials
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