Evidence map›Paper›PMID 30572609›Full record

ArticleMolecules (Basel, Switzerland)2018

Synthesis and Evaluation of 3-Substituted-4-(quinoxalin-6-yl) Pyrazoles as TGF-β Type I Receptor Kinase Inhibitors.

Li-Min Zhao, Zhen Guo, Yi-Jie Xue, Jun Zhe Min, Wen-Jing Zhu, Xiang-Yu Li, Hu-Ri Piao, Cheng Hua Jin

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Chemistry and Biological Activity of 11Molecules (Basel, Switzerland) · 2026
    Review
  2. Article
  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Li-Min ZhaoCollege of Pharmacy, Yanbian University, 977 Gongyuan Road, Yanji 133002, China. 13043384228@163.com.
Zhen GuoCollege of Pharmacy, Yanbian University, 977 Gongyuan Road, Yanji 133002, China. guozhen0921521@163.com.
Yi-Jie XueCollege of Pharmacy, Yanbian University, 977 Gongyuan Road, Yanji 133002, China. 17111030018@fudan.edu.cn.
Jun Zhe MinCollege of Pharmacy, Yanbian University, 977 Gongyuan Road, Yanji 133002, China. junzhemin23@163.com.
Wen-Jing ZhuCollege of Pharmacy, Yanbian University, 977 Gongyuan Road, Yanji 133002, China. wenjing077@163.com.
Xiang-Yu LiCollege of Pharmacy, Yanbian University, 977 Gongyuan Road, Yanji 133002, China. 15944282596@163.com.
Hu-Ri PiaoCollege of Pharmacy, Yanbian University, 977 Gongyuan Road, Yanji 133002, China. piaohr@ybu.edu.cn.
Cheng Hua JinCollege of Pharmacy, Yanbian University, 977 Gongyuan Road, Yanji 133002, China. jinchenghua@ybu.edu.cn.ORCID 0000-0001-5534-4845

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The transforming growth factor-β (TGF-β), in which overexpression has been associated with various diseases, has become an attractive molecular target for the treatment of cancers. Thirty-two quinoxaline-derivatives of 3-substituted-4-(quinoxalin-6-yl) pyrazoles

Indexed as

Enzyme InhibitorsMolecular Docking SimulationPyrazolesQuinolinesReceptor, Transforming Growth Factor-beta Type IStructure-Activity RelationshipEnzyme InhibitorsLY-2157299PyrazolesQuinolinesReceptor, Transforming Growth Factor-beta Type IALK5 inhibitordockingkinase assayselectivityTGF-β

Identifiers

PMID30572609
PMCPMC6320941

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.