Evidence map›Paper›PMID 30572569›Full record

ArticleNutrients2018

Gut Microbiota and Endothelial Dysfunction Markers in Obese Mexican Children and Adolescents.

Khemlal Nirmalkar, Selvasankar Murugesan, María Luisa Pizano-Zárate, Loan Edel Villalobos-Flores, Cristina García-González, Rosa María Morales-Hernández, Jorge Arturo Nuñez-Hernández, Fernando Hernández-Quiroz, María Del Socorro Romero-Figueroa, César Hernández-Guerrero and 2 more

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 1 pooled it
5.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 1 synthesis or guideline pooled it, 122 citations in OpenAlex.

  1. Diet, adiposity, and the gut microbiota from infancy to adolescence: A systematic review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2021
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11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Khemlal NirmalkarDepartamento de Genética y Biología Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (Cinvestav), Av. Instituto Politécnico Nacional 2508, Ciudad de México 07360, Mexico. nirmalkar@cinvestav.mx.ORCID 0000-0001-6732-9175
Selvasankar MurugesanDepartamento de Genética y Biología Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (Cinvestav), Av. Instituto Politécnico Nacional 2508, Ciudad de México 07360, Mexico. selvasankarbio@gmail.com.ORCID 0000-0001-8386-6536
María Luisa Pizano-ZárateDepartamento de Nutrición y Bioprogramación, Instituto Nacional de Perinatología, Ciudad de México 11000, Mexico. pizanozarate@yahoo.com.ORCID 0000-0002-2190-6421
Loan Edel Villalobos-FloresDepartamento de Genética y Biología Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (Cinvestav), Av. Instituto Politécnico Nacional 2508, Ciudad de México 07360, Mexico. lvillalobos@cinvestav.mx.
Cristina García-GonzálezDepartamento de Nutrición y Bioprogramación, Instituto Nacional de Perinatología, Ciudad de México 11000, Mexico. n.cristinagarcia@hotmail.com.
Rosa María Morales-HernándezDepartamento de Nutrición y Bioprogramación, Instituto Nacional de Perinatología, Ciudad de México 11000, Mexico. rmh080868@yahoo.com.
Jorge Arturo Nuñez-HernándezDepartamento Clínico de Pediatría, Hospital 220 IMSS, Toluca 50150, Mexico. drjanh@hotmail.com.
Fernando Hernández-QuirozDepartamento de Genética y Biología Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (Cinvestav), Av. Instituto Politécnico Nacional 2508, Ciudad de México 07360, Mexico. fernando.hernandez@cinvestav.mx.
María Del Socorro Romero-FigueroaCoordinación de Investigación en Salud, IMSS, Toluca 50000, Mexico. maria.romero@imss.gob.mx.
César Hernández-GuerreroDepartamento de Salud, Universidad Iberoamericana, Ciudad de México 01219, Mexico. cesar.hernandez@ibero.mx.
Carlos Hoyo-VadilloDepartamento de Farmacología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (Cinvestav), Av. Instituto Politécnico Nacional 2508, Ciudad de México 07360, Mexico. citocromo@cinvestav.mx.
Jaime García-MenaDepartamento de Genética y Biología Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (Cinvestav), Av. Instituto Politécnico Nacional 2508, Ciudad de México 07360, Mexico. jgmena@cinvestav.mx.ORCID 0000-0002-0595-3711
Instituto Politécnico Nacional · MXInstituto Nacional de Perinatología · MXIbero American University · MX

Funding

Consejo Nacional de Ciencia y Tecnología CONACyT-163235 INFR-2011-01Consejo Nacional de Ciencia y Tecnología FONSEC SS/IMSS/ISSSTE-CONACYT-233361Instituto Nacional de Perinatología 212250-3310-11402-01-14
6 · The paper itself

Abstract

Obesity is a metabolic disease characterized by low-grade inflammation and accompanied by dyslipidemia and up-regulation of other bioactive molecules, creating a predisposition to endothelial dysfunction and metabolic syndrome. We studied the association between gut microbiota diversity and endothelial dysfunction (EDF) markers in obese Mexican children and adolescents. We examined clinical data including metabolic factors and EDF markers in blood samples. Gut bacterial diversity was characterized by high-throughput sequencing of V3-16S rDNA libraries. Triglycerides, insulin, homeostasis model assessment-insulin resistant (HOMA-IR), leptin, C-reactive protein (CRP), and EDF marker intercellular adhesion molecule 1 (ICAM-1) were significantly higher in obese children and adolescents. Multivariate analysis showed statistically significant positive associations between vascular cell adhesion molecule 1 (VCAM-1) and Veillonellaceae, and between ICAM-1 and

Indexed as

Pediatric ObesityAdolescentBacteriaBiomarkersCase-Control StudiesChildEndothelium, VascularFemaleGastrointestinal MicrobiomeHumansInsulin ResistanceMaleMetabolic SyndromeMexicoBiomarkersendothelial dysfunctiongut microbiotahigh throughput DNA sequencinginsulin resistancemetabolic syndromeobesity

Identifiers

PMID30572569
PMCPMC6315777
OpenAlexW2903833977

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.