Observational studyMedicine2018
The changes and prognostic value of liver function in young adults with severe burn: A retrospective observational study.
Observational study in Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Detection of Liver Dysfunction in Severe Burn Injury with Bedside Measurement of Perfusion.Medicina (Kaunas, Lithuania) · 2026Observational
- Integrated serum metabolomics reveals severity-associated exploratory metabolic signatures in burn patients.Frontiers in physiology · 2026Article
- Decoding burn trauma: biomarkers for early diagnosis of burn-induced pathologies.Biomarker research · 2024Review
- Glutamine sustains energy metabolism and alleviates liver injury in burn sepsis by promoting the assembly of mitochondrial HSP60-HSP10 complex via SIRT4 dependent protein deacetylation.Redox report : communications in free radical research · 2024Article
- The Impact of Burns Involving Over 50% of Total Body Surface Area - a Six-Year Retrospective Study.Maedica · 2024Article
- [Multicenter retrospect analysis of early clinical features and analysis of risk factors on prognosis of elderly patients with severe burns].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2024Article
- Burn-Induced Apoptosis in the Livers of Aged Mice Is Associated With Caspase Cleavage of Bcl-xL.The Journal of surgical research · 2023Article
- Transcriptomics, metabolomics, and in-silico drug predictions for liver damage in young and aged burn victims.Communications biology · 2023Article
- Histamine H1 receptor antagonist attenuates catecholamine surge and organ injury after severe burns.Frontiers in endocrinology · 2023Article
- Systemic anti-inflammatory effects of mesenchymal stem cells in burn: A systematic review of animal studies.Journal of clinical and translational research · 2022Review
- [Effects and mechanism of diammonium glycyrrhizinate on liver injury in severely scalded rats].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2022Article
- Trajectories of longitudinal biomarkers for mortality in severely burned patients.Scientific reports · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To analyze the changes in liver functions and the relationship between alterations in liver function and mortality risk in young adults with third-degree burn wounds on over 90% of the total body surface area (TBSA).A total of 23 fatally burned factory workers in an inflammable dust explosion and fire were enrolled from 2 intensive care units. Clinical data, particularly the laboratory tests for liver function, were retrospectively analyzed and compared between the survivor and non-survivor groups.Compared to survivors, non-survivors had significantly higher total bilirubin (TBIL), glutamate-pyruvate transaminase (GPT), glutamic-oxaloacetic transaminase, alkaline phosphatase, prothrombin time, and activated partial thromboplastin time (APTT) at the terminal point of this study (P <.05). In addition, the peak values of TBIL, GPT, and longer APTT were higher in non-survivors than in survivors during hospital course, and the peak values of TBIL was one of major prognostic factors for mortality risk. Furthermore, at the first 2 weeks, the cumulative survival rates were significantly lower in patients with liver dysfunction than those without liver dysfunction (P <.01).Our findings show that the great changes in liver function occurred in first 2 weeks after severe burns. Liver dysfunction may have an effect on clinical outcomes of post-burn. Measures to protect liver function and prevent from deterioration could be beneficial in improvement survival rate, especially during the first 2 weeks.
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Registered trials
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