SynthesisMedicine2018
FIB-4 index serves as a noninvasive prognostic biomarker in patients with hepatocellular carcinoma: A meta-analysis.
Synthesis in Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- KASL clinical practice guidelines for noninvasive tests to assess liver fibrosis in chronic liver disease.Clinical and molecular hepatology · 2024Guideline
- Pooled it
- Prognostic Value of Preoperative Inflammatory, Hematological, and Metabolic Blood Indices in Endometrioid-Type Endometrial Cancer: A Retrospective Cohort Study.Medicina (Kaunas, Lithuania) · 2026Article
- Preoperative FIB-4 Index as a Potential Factor Associated With Severe Postoperative Complications and Endogenous Organ Failure After Hepatectomy for Hepatocellular Carcinoma.Annals of gastroenterological surgery · 2026Article
- Preoperative FAN score predicts survival outcomes after radical cystectomy for bladder cancer.BJUI compass · 2026Article
- The Fibrosis-4 score is associated with overall mortality and severe haematological toxicity in older patients with cancer: Analysis of two prospective cohort studies.International journal of cancer · 2025Article
- Secreted lumican from the tumor microenvironment potentiates HCC stemness and progression.Hepatology communications · 2025Article
- Clinical Significance of Fibrosis 4 Index in Early-stage Hepatocellular Carcinoma Patients Received Ultrasound-guided Microwave Ablation.Applied biochemistry and biotechnology · 2025Article
- The adverse characteristics of hepatocellular carcinoma in the non-cirrhotic liver disproportionately disadvantage Black patients.Cancer medicine · 2024Article
- The Impact of Clinical Prognosis of Viral Hepatitis in Head and Neck Cancer Patients Receiving Concurrent Chemoradiotherapy.Biomedicines · 2023Article
- Clinical manifestation, staging and prognosis of hepatocellular carcinoma in Gambian patients.BMC gastroenterology · 2023Article
- Patients with type 2 diabetes and elevated fibrosis-4 are under-referred to hepatology and have unrecognized hepatic decompensation.Journal of gastroenterology and hepatology · 2022Article
- Hepatectomy outcomes in patients with hepatitis C virus-related hepatocellular carcinoma with or without cirrhosis.Annals of surgical treatment and research · 2022Article
- Realization of improved outcomes following liver resection in hepatocellular carcinoma patients aged 75 years and older.Annals of surgical treatment and research · 2021Article
- The prognostic values of serum markers in hepatocellular carcinoma after invasive therapies based on real-world data.Journal of clinical laboratory analysis · 2021Article
- FIB-4 First in the Diagnostic Algorithm of Metabolic-Dysfunction-Associated Fatty Liver Disease in the Era of the Global Metabodemic.Life (Basel, Switzerland) · 2021Review
- Nomograms based on clinicopathological factors and inflammatory indicators for prediction of early and late recurrence of hepatocellular carcinoma after surgical resection for patients with chronic hepatitis B.Annals of translational medicine · 2021Article
- Prognostic nomogram for hepatocellular carcinoma with fibrosis of varying degrees: a retrospective cohort study.Annals of translational medicine · 2020Article
- Substantial risk of recurrence even after 5 recurrence-free years in early-stage hepatocellular carcinoma patients.Clinical and molecular hepatology · 2020Article
- Observational
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLiver fibrosis index FIB-4 has been reported to be linked with hepatocellular carcinoma (HCC) prognosis, but the results were not consistent. This study aimed to synthetically explore the relationship between FIB-4 and clinical outcomes of HCC.
methodsA number of online databases were searched for relevant articles published before March 1, 2018. Hazard ratios (HRs) with 95% confidence intervals (95% CIs) were calculated to assess the prognostic value of the FIB-4 index in patients with HCC using Stata SE 12.0.
resultsEight articles (including 10 cohort studies) with 3485 HCC patients were finally included for analysis. The pooled results showed that FIB-4 index was significantly associated with overall survival (OS) for patients with HCC (HR = 1.74, 95% CI: 1.41-2.07, P <.001). And HCC patients with higher FIB-4 score were at significantly greater risk of recurrence 1.53 (95% CI: 1.29-1.78, P <.001). Subgroup analysis based on the treatment, stage and analysis type also confirmed the prognostic values of the FIB-4 score for OS and recurrence-free survival (RFS) in HCC.
conclusionsFIB-4 index might be a useful predictive marker in patients with HCC.
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