ArticleDevelopmental and comparative immunology2019
The planarian Schmidtea mediterranea is a new model to study host-pathogen interactions during fungal infections.
Article in Developmental and comparative immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- An optimized protocol forbioRxiv : the preprint server for biology · 2025Article
- Explosive cytotoxicity of 'ruptoblasts' bridges hormonal surveillance and immune defense.bioRxiv : the preprint server for biology · 2025Article
- map3k1 suppresses terminal differentiation of migratory eye progenitors in planarian regeneration.PLoS genetics · 2025Article
- Article
- Triazine-Based Small Molecules: A Potential New Class of Compounds in the Antifungal Toolbox.Pathogens (Basel, Switzerland) · 2023Article
- Polyphyllin I EffectsEvidence-based complementary and alternative medicine : eCAM · 2023Article
- A Planarian Model System to Study Host-Pathogen Interactions.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Non-traditional roles of immune cells in regeneration: an evolutionary perspective.Development (Cambridge, England) · 2022Article
- Culturomics revealed the bacterial constituents of the microbiota of a 10-year-old laboratory culture of planarian species S. mediterranea.Scientific reports · 2021Article
- The SPFH Protein Superfamily in Fungi: Impact on Mitochondrial Function and Implications in Virulence.Microorganisms · 2021Review
- Chryseobacterium schmidteae sp. nov. a novel bacterial species isolated from planarian Schmidtea mediterranea.Scientific reports · 2021Article
- Planarians (Platyhelminthes)-An Emerging Model Organism for Investigating Innate Immune Mechanisms.Frontiers in cellular and infection microbiology · 2021Review
- Article
- Epithelial Infection WithFrontiers in microbiology · 2020Article
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Authors and funding
5 authors.
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Abstract
Candida albicans is one of the most common fungal pathogens of humans. Currently, there are limitations in the evaluation of C. albicans infection in existing animal models, especially in terms of understanding the influence of specific infectious stages of the fungal pathogen on the host. We show that C. albicans infects, grows and invades tissues in the planarian flatworm Schmidtea mediterranea, and that the planarian responds to infection by activating components of the host innate immune system to clear and repair host tissues. We study different stages of C. albicans infection and demonstrate that planarian stem cells increase division in response to fungal infection, a process that is likely evolutionarily conserved in metazoans. Our results implicate MORN2 and TAK1/p38 signaling pathways as possible mediators of the host innate immune response to fungal infection. We propose the use of planarians as a model system to investigate host-pathogen interactions during fungal infections.
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