Evidence map›Paper›PMID 30571965›Full record

ArticleArchives of biochemistry and biophysics2019

Dual role of inorganic polyphosphate in cardiac myocytes: The importance of polyP chain length for energy metabolism and mPTP activation.

Lea K Seidlmayer, Maria R Gomez-Garcia, Toshikazu Shiba, George A Porter, Evgeny V Pavlov, Donald M Bers, Elena N Dedkova

Open access · greenAbstract read
In one paragraph

Article in Archives of biochemistry and biophysics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 44 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Elevated phosphate levels in CKD - a direct threat for the heart.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. HRG to the Rescue.Arteriosclerosis, thrombosis, and vascular biology · 2024
    Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. The Glacier Ice Worm,Biology · 2022
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 2 countries.

Lea K SeidlmayerDepartment of Internal Medicine, Cardiology, University Hospital Würzburg, Würzburg, Germany; Comprehensive Heart Failure Center, University of Würzburg, Würzburg, Germany.
Maria R Gomez-GarciaSensor Kinesis, Stanford University, Stanford, CA, USA.
Toshikazu ShibaRegenetiss, Inc., Higashi, Kunitachi, Tokyo, Japan.
George A PorterDepartment of Pediatrics, Pharmacology and Physiology, and Medicine (Aab Cardiovascular Research Institute), University of Rochester School of Medicine, Rochester, NY, USA.
Evgeny V PavlovDepartment of Basic Science and Craniofacial Biology, School of Dentistry, New York University, New York, NY, USA.
Donald M BersDepartment of Pharmacology, School of Medicine, University of California, Davis, CA, USA.
Elena N DedkovaDepartment of Pharmacology, School of Medicine, University of California, Davis, CA, USA. Electronic address: ededkova@ucdavis.edu.
New York University · USStanford University · USUniversity of California, Davis · USUniversity of California System · USUniversity of Rochester · USUniversity of Würzburg · DE

Funding

Molecular examination of mitochondrial calcium controlR01HL132831 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI BERS, DONALD M, MOLKENTIN, JEFFERY D · 2016 to 2024
$5.9M
NHLBI NIH HHS R01 HL132831
6 · The paper itself

Abstract

We have previously demonstrated that inorganic polyphosphate (polyP) is a potent activator of the mitochondrial permeability transition pore (mPTP) in cardiac myocytes. PolyP depletion protected against Ca

Indexed as

AnimalsEnergy MetabolismInorganic ChemicalsMiceMice, Inbred C57BLMitochondrial Membrane Transport ProteinsMitochondrial Permeability Transition PoreMyocytes, CardiacPolyphosphatesInorganic ChemicalsMitochondrial Membrane Transport ProteinsMitochondrial Permeability Transition PorePolyphosphatesAnimal models of human diseaseATP synthaseBioenergeticsInorganic polyphosphateIschemia-reperfusion injuryMetabolismMitochondrial metabolismMitochondrial permeability transition pore

Identifiers

PMID30571965
PMCPMC8186898
OpenAlexW2903827094

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.