Evidence map›Paper›PMID 30571927›Full record

ArticleCancer biology & therapy2019

Neratinib and entinostat combine to rapidly reduce the expression of K-RAS, N-RAS, Gα

Laurence Booth, Jane L Roberts, Cindy Sander, Alshad S Lalani, John M Kirkwood, John F Hancock, Andrew Poklepovic, Paul Dent

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer biology & therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 49 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Laurence Bootha Departments of Biochemistry and Molecular Biology , Virginia Commonwealth University , Richmond , VA , USA.
Jane L Robertsa Departments of Biochemistry and Molecular Biology , Virginia Commonwealth University , Richmond , VA , USA.
Cindy Sanderb Melanoma and Skin Cancer Program, Hillman Cancer Research Pavilion Laboratory , University of Pittsburgh Cancer Institute , Pittsburgh , PA , USA.ORCID 0000-0002-4136-1342
Alshad S Lalanic Puma Biotechnology Inc ., Los Angeles , CA , USA.
John M Kirkwoodb Melanoma and Skin Cancer Program, Hillman Cancer Research Pavilion Laboratory , University of Pittsburgh Cancer Institute , Pittsburgh , PA , USA.
John F Hancockd Department of Integrative Biology and Pharmacology , University of Texas Health Science Center , Houston , TX , USA.
Andrew Poklepovice Departments of Medicine , Virginia Commonwealth University , Richmond , VA , USA.
Paul Denta Departments of Biochemistry and Molecular Biology , Virginia Commonwealth University , Richmond , VA , USA.
Virginia Commonwealth University · USUPMC Hillman Cancer Center · USPuma Biotechnology (United States) · USThe University of Texas Health Science Center at Houston · US

Funding

Pemetrexed and sildenafil for lung cancerR01CA192613 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI DENT, PAUL · 2015 to 2019
$1.6M
NCI NIH HHS R01 CA192613
6 · The paper itself

Abstract

There is no efficacious standard of care therapy for uveal melanoma. Unlike cutaneous disease, uveal melanoma does not exhibit RAS mutations but instead contains mutations with ~90% penetrance in either Gα

Indexed as

Antineoplastic Combined Chemotherapy ProtocolsAutophagyBenzamidesCell Line, TumorDown-RegulationDrug Screening Assays, AntitumorDrug SynergismGene Expression Regulation, NeoplasticGTP-Binding Protein alpha SubunitsGTP-Binding Protein alpha Subunits, Gq-G11GTP PhosphohydrolasesHumansMelanomaMembrane ProteinsProto-Oncogene Proteins p21(ras)PyridinesBenzamidesentinostatGNA11 protein, humanGNAQ protein, humanGTP-Binding Protein alpha SubunitsGTP-Binding Protein alpha Subunits, Gq-G11GTP PhosphohydrolasesKRAS protein, humanMembrane ProteinsneratinibNRAS protein, humanProto-Oncogene Proteins p21(ras)PyridinesQuinolinesautophagyG alphaHDAC inhibitorneratinibRAS

Identifiers

PMID30571927
PMCPMC6606002
OpenAlexW2906325618

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.