SynthesisPloS one2018
Sex differences in post-stroke aphasia rates are caused by age. A meta-analysis and database query.
Synthesis in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Meta-analysis and systematic review of the relationship between sex and the risk or incidence of poststroke aphasia and its types.BMC geriatrics · 2024Pooled it
- Does acupuncture therapy improve language function of patients with aphasia following ischemic stroke? A systematic review and meta-analysis.NeuroRehabilitation · 2022Pooled it
- The economic burden of stroke: a systematic review of cost of illness studies.Journal of medicine and lifePooled it
- Sex differences in location of initial diagnosis and discharge destination among medicare fee-for-service beneficiaries with post-stroke aphasia.Frontiers in stroke · 2026Article
- Advances in Neuromodulation Techniques for Aphasia Rehabilitation: A Comprehensive Review.Medical science monitor : international medical journal of experimental and clinical research · 2025Review
- Multifactorial interplay on language recovery following left-hemispheric stroke: A retrospective study.Journal of neuropsychology · 2025Article
- A multicenter study on the sex difference of dysfunctions among rehabilitation outpatients in China.Scientific reports · 2024Article
- The role of gender in cognitive outcomes from stroke.Journal of the International Neuropsychological Society : JINS · 2023Article
- Bayesian stroke modeling details sex biases in the white matter substrates of aphasia.Communications biology · 2023Article
- Sex Differences in the Long-Term Consequences of Stroke.Current topics in behavioral neurosciences · 2023Review
- Structural disconnections associated with language impairments in chronic post-stroke aphasia using disconnectome maps.Cortex; a journal devoted to the study of the nervous system and behavior · 2022Article
- Predictors of Therapy Response in Chronic Aphasia: Building a Foundation for Personalized Aphasia Therapy.Journal of stroke · 2022Review
- Machine learning-based multimodal prediction of language outcomes in chronic aphasia.Human brain mapping · 2021Article
- Factors Associated With Adherence to Self-Managed Aphasia Therapy Practice on a Computer-A Mixed Methods Study Alongside a Randomized Controlled Trial.Frontiers in neurology · 2020Article
- Leukoaraiosis Is Associated With a Decline in Language Abilities in Chronic Aphasia.Neurorehabilitation and neural repair · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStudies have suggested that aphasia rates are different in men and women following stroke. One hypothesis says that men have more lateralized language function than women. Given unilateral stroke, this would lead to a prediction of men having higher aphasia rates than women. Another line of observations suggest that women are more severely affected by stroke, which could lead to a higher aphasia rate among women. An additional potential confounding variable could be age, given that women are typically older at the time of stroke. METHODS & PROCEDURES: This study consists of two parts. First, a meta-analysis of the available reports of aphasia rates in the two sexes was conducted. A comprehensive literature search yielded 25 studies with sufficient information about both aphasia and gender. These studies included a total of 48,362 stroke patients for which aphasia rates were calculated. Second, data were extracted from an American health database (with 1,967,038 stroke patients), in order to include age and stroke severity into a regression analysis of sex differences in aphasia rates. OUTCOMES &
resultsBoth analyses revealed significantly larger aphasia rates in women than in men (1.1-1.14 ratio). This speaks against the idea that men should be more lateralized in their language function. When age and stroke severity were included as covariates, sex failed to explain any aphasia rate sex difference above and beyond that which is explained by age differences at time of stroke.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.