ArticlePloS one2018
Understanding the impact of crosslinked PCL/PEG/GelMA electrospun nanofibers on bactericidal activity.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 31 citations in OpenAlex.
- In Vivo Investigation of Osteogenesis and Angiogenesis of Modified Polycaprolactone-Hydroxyapatite-Zinc Oxide Electrospun Nanofibers Loaded with Metformin.Annals of biomedical engineering · 2025Article
- Fabrication and characterizations of 3D printed GelMA-Gel/bioactive glass scaffolds containing cerium for bone damage repair.Scientific reports · 2025Article
- Biodegradable electrospun poly(L-lactide-co-ε-caprolactone)/polyethylene glycol/bioactive glass composite scaffold for bone tissue engineering.Journal of biomedical materials research. Part B, Applied biomaterials · 2024Article
- Hydrogel-Impregnated Self-Oxygenating Electrospun Scaffolds for Bone Tissue Engineering.Bioengineering (Basel, Switzerland) · 2023Article
- Extracellular Vesicle-Based Hydrogels for Wound Healing Applications.International journal of molecular sciences · 2023Review
- Engineering multifunctional bactericidal nanofibers for abdominal hernia repair.Communications biology · 2021Article
- Impact of Endotoxins in Gelatine Hydrogels on Chondrogenic Differentiation and Inflammatory Cytokine Secretion In Vitro.International journal of molecular sciences · 2020Article
- Printing 3D Hydrogel Structures Employing Low-Cost Stereolithography Technology.Journal of functional biomaterials · 2020Article
- Antifungal susceptibility of Candida species to copper oxide nanoparticles on polycaprolactone fibers (PCL-CuONPs).PloS one · 2020Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Herein, we report the design of electrospun ultrathin fibers based on the combination of three different polymers polycaprolactone (PCL), polyethylene glycol (PEG), and gelatin methacryloyl (GelMA), and their potential bactericidal activity against three different bacteria Staphylococcus aureus (S. aureus), Pseudomonas aeruginosa (P. aeruginosa), and Methicillin-resistant Staphylococcus aureus (MRSA). We evaluated the morphology, chemical structure and wettability before and after UV photocrosslinking of the produced scaffolds. Results showed that the developed scaffolds presented hydrophilic properties after PEG and GelMA incorporation. Moreover, they were able to significantly reduce gram-positive, negative, and MRSA bacteria mainly after UV photocrosslinking (PCL:PEG:GelMa-UV). Furthermore, we performed a series of study for gaining a better mechanistic understanding of the scaffolds bactericidal activity through protein adsorption study and analysis of the reactive oxygen species (ROS) levels. Furthermore, the in vivo subcutaneous implantation performed in rats confirmed the biocompatibility of our designed scaffolds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.