Evidence map›Paper›PMID 30571601›Full record

ArticleJournal of the American Heart Association2018

Leveraging the Electronic Health Record to Create an Automated Real-Time Prognostic Tool for Peripheral Arterial Disease.

Adelaide M Arruda-Olson, Naveed Afzal, Vishnu Priya Mallipeddi, Ahmad Said, Homam Moussa Pacha, Sungrim Moon, Alisha P Chaudhry, Christopher G Scott, Kent R Bailey, Thom W Rooke and 7 more

Abstract read
In one paragraph

Article in Journal of the American Heart Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

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  17. Natural Language Processing for the Evaluation of Methodological Standards and Best Practices of EHR-based Clinical Research.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2020
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Adelaide M Arruda-Olson1 Department of Cardiovascular Medicine Mayo Clinic Rochester MN.
Naveed Afzal2 Department of Health Sciences Research Mayo Clinic Rochester MN.
Vishnu Priya Mallipeddi1 Department of Cardiovascular Medicine Mayo Clinic Rochester MN.
Ahmad Said1 Department of Cardiovascular Medicine Mayo Clinic Rochester MN.
Homam Moussa Pacha1 Department of Cardiovascular Medicine Mayo Clinic Rochester MN.
Sungrim Moon2 Department of Health Sciences Research Mayo Clinic Rochester MN.
Alisha P Chaudhry1 Department of Cardiovascular Medicine Mayo Clinic Rochester MN.
Christopher G Scott2 Department of Health Sciences Research Mayo Clinic Rochester MN.
Kent R Bailey2 Department of Health Sciences Research Mayo Clinic Rochester MN.
Thom W Rooke1 Department of Cardiovascular Medicine Mayo Clinic Rochester MN.
Paul W Wennberg1 Department of Cardiovascular Medicine Mayo Clinic Rochester MN.
Vinod C Kaggal2 Department of Health Sciences Research Mayo Clinic Rochester MN.
Gustavo S Oderich3 Division of Vascular and Endovascular Surgery Mayo Clinic Rochester MN.
Iftikhar J Kullo1 Department of Cardiovascular Medicine Mayo Clinic Rochester MN.
Rick A Nishimura1 Department of Cardiovascular Medicine Mayo Clinic Rochester MN.
Rajeev Chaudhry4 Division of Primary Care Medicine and Center of Translational Informatics and Knowledge Management Mayo Clinic Rochester MN.
Hongfang Liu2 Department of Health Sciences Research Mayo Clinic Rochester MN.

Funding

Genomic Basis of Susceptibility to COVID-19 Infection and its ComplicationsU01HG006379 · NHGRI · MAYO CLINIC ROCHESTER · PI Richard R. Sharp · 2011 to 2026
$16.5M
Open Health Natural Language Processing CollaboratoryU01TR002062 · NCATS · MAYO CLINIC ROCHESTER · PI JIANG, XIAOQIAN, LIU, HONGFANG · 2017 to 2021
$7.6M
Secondary use of EMRs for surgical complication surveillanceR01EB019403 · NIBIB · MAYO CLINIC ROCHESTER · PI LIU, HONGFANG, STORLIE, CURTIS · 2015 to 2022
$3.8M
Novel Informatics Approaches for Ascertainment of PAD Status and Adverse OutcomesK01HL124045 · NHLBI · MAYO CLINIC ROCHESTER · PI ARRUDA-OLSON, ADELAIDE MARIA MARTINS · 2015 to 2019
$820k
NCATS NIH HHS U01 TR002062NHGRI NIH HHS U01 HG006379NHLBI NIH HHS K01 HL124045NIBIB NIH HHS R01 EB019403
6 · The paper itself

Abstract

Background Automated individualized risk prediction tools linked to electronic health records ( EHR s) are not available for management of patients with peripheral arterial disease. The goal of this study was to create a prognostic tool for patients with peripheral arterial disease using data elements automatically extracted from an EHR to enable real-time and individualized risk prediction at the point of care. Methods and Results A previously validated phenotyping algorithm was deployed to an EHR linked to the Rochester Epidemiology Project to identify peripheral arterial disease cases from Olmsted County, MN, for the years 1998 to 2011. The study cohort was composed of 1676 patients: 593 patients died over 5-year follow-up. The c-statistic for survival in the overall data set was 0.76 (95% confidence interval [CI], 0.74-0.78), and the c-statistic across 10 cross-validation data sets was 0.75 (95% CI, 0.73-0.77). Stratification of cases demonstrated increasing mortality risk by subgroup (low: hazard ratio, 0.35 [95% CI, 0.21-0.58]; intermediate-high: hazard ratio, 2.98 [95% CI, 2.37-3.74]; high: hazard ratio, 8.44 [95% CI, 6.66-10.70], all P<0.0001 versus the reference subgroup). An equation for risk calculation was derived from Cox model parameters and β estimates. Big data infrastructure enabled deployment of the real-time risk calculator to the point of care via the EHR . Conclusions This study demonstrates that electronic tools can be deployed to EHR s to create automated real-time risk calculators to predict survival of patients with peripheral arterial disease. Moreover, the prognostic model developed may be translated to patient care as an automated and individualized real-time risk calculator deployed at the point of care.

Indexed as

Electronic Health RecordsAgedAlgorithmsDiagnosis, Computer-AssistedFemaleHumansMalePeripheral Arterial DiseasePrognosisProportional Hazards ModelsRisk AssessmentRisk Factorselectronic health recordperipheral artery diseaseprognosis

Identifiers

PMID30571601
PMCPMC6405562

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.