Evidence map›Paper›PMID 30571558›Full record

ArticleHypertension (Dallas, Tex. : 1979)2019

Norepinephrine-Induced Stimulation of Kir4.1/Kir5.1 Is Required for the Activation of NaCl Transporter in Distal Convoluted Tubule.

Xin-Peng Duan, Li Gu, Yu Xiao, Zhong-Xiuzi Gao, Peng Wu, Yun-Hong Zhang, Xin-Xin Meng, Jun-Lin Wang, Dan-Dan Zhang, Dao-Hong Lin and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Inwardly rectifying KAmerican journal of physiology. Cell physiology · 2022
    Review
  5. Article
  6. Article
  7. Landscape of GPCR expression along the mouse nephron.American journal of physiology. Renal physiology · 2021
    Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
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  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Xin-Peng DuanFrom the Department of Physiology, Harbin Medical University, China (X.-P.D., L.G., Y.X., Y.-H.Z., X.-X.M., J.-L.W., D.-D.Z., W.-H.W., R.G.).
Li GuFrom the Department of Physiology, Harbin Medical University, China (X.-P.D., L.G., Y.X., Y.-H.Z., X.-X.M., J.-L.W., D.-D.Z., W.-H.W., R.G.).
Yu XiaoFrom the Department of Physiology, Harbin Medical University, China (X.-P.D., L.G., Y.X., Y.-H.Z., X.-X.M., J.-L.W., D.-D.Z., W.-H.W., R.G.).
Zhong-Xiuzi GaoDepartment of Pharmacology, New York Medical College, Valhalla (Z.-X.G., P.W., D.-H.L., W.-H.W.).
Peng WuDepartment of Pharmacology, New York Medical College, Valhalla (Z.-X.G., P.W., D.-H.L., W.-H.W.).
Yun-Hong ZhangFrom the Department of Physiology, Harbin Medical University, China (X.-P.D., L.G., Y.X., Y.-H.Z., X.-X.M., J.-L.W., D.-D.Z., W.-H.W., R.G.).
Xin-Xin MengFrom the Department of Physiology, Harbin Medical University, China (X.-P.D., L.G., Y.X., Y.-H.Z., X.-X.M., J.-L.W., D.-D.Z., W.-H.W., R.G.).
Jun-Lin WangFrom the Department of Physiology, Harbin Medical University, China (X.-P.D., L.G., Y.X., Y.-H.Z., X.-X.M., J.-L.W., D.-D.Z., W.-H.W., R.G.).
Dan-Dan ZhangFrom the Department of Physiology, Harbin Medical University, China (X.-P.D., L.G., Y.X., Y.-H.Z., X.-X.M., J.-L.W., D.-D.Z., W.-H.W., R.G.).
Dao-Hong LinDepartment of Pharmacology, New York Medical College, Valhalla (Z.-X.G., P.W., D.-H.L., W.-H.W.).
Wen-Hui WangFrom the Department of Physiology, Harbin Medical University, China (X.-P.D., L.G., Y.X., Y.-H.Z., X.-X.M., J.-L.W., D.-D.Z., W.-H.W., R.G.).
Ruimin GuFrom the Department of Physiology, Harbin Medical University, China (X.-P.D., L.G., Y.X., Y.-H.Z., X.-X.M., J.-L.W., D.-D.Z., W.-H.W., R.G.).
Harbin Medical University · CNNew York Medical College · US

Funding

Role of Kir4.1 in Regulating NCC and ROMK in DCTR01DK054983 · NIDDK · NEW YORK MEDICAL COLLEGE · PI ELLISON, DAVID H, WANG, WENHUI · 2001 to 2020
$7.4M
Kir5.1 regulates Kir4.1 ubiquitination by Nedd4-2 in DCTR01DK115366 · NIDDK · NEW YORK MEDICAL COLLEGE · PI LIN, DAO-HONG · 2018 to 2021
$1.5M
Role of Kir4.1 in Regulating NCC and ROMK in DCTR56DK054983 · NIDDK · NEW YORK MEDICAL COLLEGE · PI ELLISON, DAVID H, WANG, WENHUI · 2021 to 2021
$100k
NIDDK NIH HHS R01 DK054983NIDDK NIH HHS R01 DK115366NIDDK NIH HHS R56 DK054983
6 · The paper itself

Abstract

The stimulation of β-adrenergic receptor increases thiazide-sensitive NaCl cotransporter (NCC), an effect contributing to salt-sensitive hypertension by sympathetic stimulation. We now test whether the stimulation of β-adrenergic receptor-induced activation of NCC is achieved through activating basolateral Kir4.1 in the distal convoluted tubule (DCT). Application of norepinephrine increased the basolateral 40 pS K

Indexed as

Ion TransportAdrenergic beta-AgonistsAdrenergic beta-AntagonistsAnimalsIsoproterenolKcnj10 ChannelKidney Tubules, DistalKir5.1 ChannelMiceMice, KnockoutNorepinephrinePotassium Channels, Inwardly RectifyingPropranololReceptors, Adrenergic, betaSolute Carrier Family 12, Member 1Solute Carrier Family 12, Member 3Adrenergic beta-AgonistsAdrenergic beta-AntagonistsIsoproterenolKcnj10 ChannelKir5.1 ChannelNorepinephrinePotassium Channels, Inwardly RectifyingPropranololReceptors, Adrenergic, betaSlc12a1 protein, mouseSolute Carrier Family 12, Member 1Solute Carrier Family 12, Member 3hypertensionion transportisoproterenolnorepinephrinepropranolol

Identifiers

PMID30571558
PMCPMC6319266
OpenAlexW2900856096

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.