ArticleHypertension (Dallas, Tex. : 1979)2019
Novel Treatment of Hypertension by Specifically Targeting E2F for Restoration of Endothelial Dihydrofolate Reductase and eNOS Function Under Oxidative Stress.
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Article in Hypertension (Dallas, Tex. : 1979), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
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Who cites it
21 citing papers in PubMed, 26 citations in OpenAlex.
- Discovery of gene-alcohol interaction loci influencing blood pressure in 1.1 million individuals from multiple populations.Research square · 2026Article
- Attenuation of advanced atherosclerosis and aortic aneurysm in hph-1/apoE DKO mice by folic acid and DHFR overexpression.Frontiers in physiology · 2026Article
- Corynoline enhances sorafenib sensitivity in hepatocellular carcinoma via NOS3-mediated ROS production.Chinese medicine · 2025Article
- Role of Inflammatory and Proresolving Mediators in Endothelial Dysfunction.Basic & clinical pharmacology & toxicology · 2025Review
- SNX3 mediates heart failure by interacting with HMGB1 and subsequently facilitating its nuclear-cytoplasmic translocation.Acta pharmacologica Sinica · 2025Article
- Reversal of Pulmonary Hypertension in a Human-Like Model: Therapeutic Targeting of Endothelial DHFR.Circulation research · 2024Article
- Targeting cytokine-like protein FAM3D lowers blood pressure in hypertension.Cell reports. Medicine · 2023Article
- Increased NOX2 expression in astrocytes leads to eNOS uncoupling through dihydrofolate reductase in endothelial cells after subarachnoid hemorrhage.Frontiers in molecular neuroscience · 2023Article
- Systems Biology Analysis of Temporal Dynamics That Govern Endothelial Response to Cyclic Stretch.Biomolecules · 2022Review
- Diagnostic and predictive values of circulating tetrahydrobiopterin levels as a novel biomarker in patients with thoracic and abdominal aortic aneurysms.Redox biology · 2022Article
- Flavored and Nicotine-Containing E-Cigarettes Induce Impaired Angiogenesis and Diabetic Wound Healing via Increased Endothelial Oxidative Stress and Reduced NO Bioavailability.Antioxidants (Basel, Switzerland) · 2022Article
- Robust therapeutic effects on COVID-19 of novel small molecules: Alleviation of SARS-CoV-2 S protein induction of ACE2/TMPRSS2, NOX2/ROS, and MCP-1.Frontiers in cardiovascular medicine · 2022Article
- Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function.Nature genetics · 2022Article
- Article
- Targeting MicroRNA-192-5p, a Downstream Effector of NOXs (NADPH Oxidases), Reverses Endothelial DHFR (Dihydrofolate Reductase) Deficiency to Attenuate Abdominal Aortic Aneurysm Formation.Hypertension (Dallas, Tex. : 1979) · 2021Article
- Network Analyses Based on Machine Learning Methods to Quantify Effects of Peptide-Protein Complexes as Drug Targets Using Cinnamon in Cardiovascular Diseases and Metabolic Syndrome as a Case Study.Frontiers in genetics · 2021Article
- Association of ECE1 gene polymorphisms and essential hypertension risk in the Northern Han Chinese: A case-control study.Molecular genetics & genomic medicine · 2020Article
- NADPH oxidases and oxidase crosstalk in cardiovascular diseases: novel therapeutic targets.Nature reviews. Cardiology · 2020Review
- Indoxyl sulfate impairs valsartan-induced neovascularization.Redox biology · 2020Article
- Endothelial retinoblastoma protein reduces abdominal aortic aneurysm development via promoting DHFR/NO pathway-mediated vasoprotection.Molecular and cellular biochemistry · 2019Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Hong LiFrom the Division of Molecular Medicine, Department of Anesthesiology, Cardiovascular Research Laboratories (H.L., Q.L., Y.Z., B.G., T.N., K.L.S., J.Y.Y., H.C.), David Geffen School of Medicine, University of California, Los Angeles.
Qiang LiFrom the Division of Molecular Medicine, Department of Anesthesiology, Cardiovascular Research Laboratories (H.L., Q.L., Y.Z., B.G., T.N., K.L.S., J.Y.Y., H.C.), David Geffen School of Medicine, University of California, Los Angeles.
Yixuan ZhangFrom the Division of Molecular Medicine, Department of Anesthesiology, Cardiovascular Research Laboratories (H.L., Q.L., Y.Z., B.G., T.N., K.L.S., J.Y.Y., H.C.), David Geffen School of Medicine, University of California, Los Angeles.
Wenting LiuDepartment of Integrative Biology and Physiology (W.L., X.Y.), David Geffen School of Medicine, University of California, Los Angeles.
Bo GuFrom the Division of Molecular Medicine, Department of Anesthesiology, Cardiovascular Research Laboratories (H.L., Q.L., Y.Z., B.G., T.N., K.L.S., J.Y.Y., H.C.), David Geffen School of Medicine, University of California, Los Angeles.
Taro NarumiFrom the Division of Molecular Medicine, Department of Anesthesiology, Cardiovascular Research Laboratories (H.L., Q.L., Y.Z., B.G., T.N., K.L.S., J.Y.Y., H.C.), David Geffen School of Medicine, University of California, Los Angeles.
Kin Lung SiuFrom the Division of Molecular Medicine, Department of Anesthesiology, Cardiovascular Research Laboratories (H.L., Q.L., Y.Z., B.G., T.N., K.L.S., J.Y.Y., H.C.), David Geffen School of Medicine, University of California, Los Angeles.
Ji Youn YounFrom the Division of Molecular Medicine, Department of Anesthesiology, Cardiovascular Research Laboratories (H.L., Q.L., Y.Z., B.G., T.N., K.L.S., J.Y.Y., H.C.), David Geffen School of Medicine, University of California, Los Angeles.
Peiqing LiuDepartment of Pharmacology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong, China (H.L., P.L.).
Xia YangDepartment of Integrative Biology and Physiology (W.L., X.Y.), David Geffen School of Medicine, University of California, Los Angeles.
Hua CaiFrom the Division of Molecular Medicine, Department of Anesthesiology, Cardiovascular Research Laboratories (H.L., Q.L., Y.Z., B.G., T.N., K.L.S., J.Y.Y., H.C.), David Geffen School of Medicine, University of California, Los Angeles.
University of California, Los Angeles · US
Funding
Angiotensin II Uncoupling of Enos in HypertensionR01HL077440 · NHLBI · UNIVERSITY OF CHICAGO · PI CAI, HUA LINDA · 2005 to 2019
$4.8MNOXs, eNOS Uncoupling and Diabetic AtherogenesisR01HL088975 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CAI, HUA LINDA · 2010 to 2019
$4.5MEndothelium-Myocardium Interaction in Netrin-1 Induced CardioprotectionR01HL119968 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CAI, HUA LINDA · 2013 to 2017
$2.5MNetrin-1 and Netrin-1 Preconditioned EPCs in Vascular ProtectionR01HL142951 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CAI, HUA LINDA · 2020 to 2023
$2.0MRole of Vascular Oxidative Stress in ObesityR01HL108701 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CAI, HUA LINDA, HARRISON, DAVID G · 2012 to 2015
$1.9MNHLBI NIH HHS R01 HL077440NHLBI NIH HHS R01 HL088975NHLBI NIH HHS R01 HL108701NHLBI NIH HHS R01 HL119968NHLBI NIH HHS R01 HL142951
Abstract
We have shown that hydrogen peroxide (H
Indexed as
Blood PressureE2F1 Transcription FactorEndothelial CellsHydrogen PeroxideHypertensionAnimalsDown-RegulationE2F2 Transcription FactorE2F3 Transcription FactorGene Regulatory NetworksMiceNitric OxideNitric Oxide Synthase Type IIIOxidation-ReductionTetrahydrofolate DehydrogenaseE2F1 Transcription FactorE2F2 Transcription FactorE2F3 Transcription FactorHydrogen PeroxideNitric OxideNitric Oxide Synthase Type IIINos3 protein, mouseTetrahydrofolate Dehydrogenaseangiotensin IIdihydrofolate reductaseE2FeNOS uncouplinghydrogen peroxidehypertensionnitric oxide
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