ArticleHypertension (Dallas, Tex. : 1979)2019
Out-of-Clinic Sympathetic Activity Is Increased in Patients With Masked Uncontrolled Hypertension.
Article in Hypertension (Dallas, Tex. : 1979), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 40 citations in OpenAlex.
- Association between hypertension phenotypes and aortic valve peak velocity: a potential tool for identifying white-coat hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Effects of perirenal fat accumulation on cardiometabolic and renal functions and mineralocorticoid receptor activation in primary aldosteronism.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Prevalence and prediction of masked uncontrolled hypertension in patients recently hospitalized for myocardial infarction.European heart journal open · 2025Article
- Blood pressure and vascular function response to maximal graded exercise tests in young men with masked hypertension.American journal of physiology. Regulatory, integrative and comparative physiology · 2025Article
- Heart rate variability: reference values and role for clinical profile and mortality in individuals with heart failure.Clinical research in cardiology : official journal of the German Cardiac Society · 2024Article
- Adverse cardiac remodeling is absent in patients with true controlled resistant hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2023Article
- Prediction of Masked Uncontrolled Hypertension Detected by Ambulatory Blood Pressure Monitoring.Diagnostics (Basel, Switzerland) · 2022Article
- Blood pressure response to standing is a strong determinant of masked hypertension in young to middle-age individuals.Journal of hypertension · 2022Article
- Analysis of Systolic Blood Pressure Level and Short-Term Variability in Masked Hypertension.Journal of healthcare engineering · 2022Article
- Association of Urine Metanephrine Levels with CardiometaBolic Risk: An Observational Retrospective Study.Journal of clinical medicine · 2021Article
- Office blood pressure measurement: A comprehensive review.Journal of clinical hypertension (Greenwich, Conn.) · 2021Review
- Masked Uncontrolled Hypertension Is Accompanied by Increased Out-of-Clinic Aldosterone Secretion.Hypertension (Dallas, Tex. : 1979) · 2021Article
- Prediction of Masked Hypertension and Masked Uncontrolled Hypertension Using Machine Learning.Frontiers in cardiovascular medicine · 2021Article
- Sex difference in sympathetic nervous system activity and blood pressure in hypertensive patients.Journal of clinical hypertension (Greenwich, Conn.) · 2021Article
- Prognostic Significance of Ambulatory BP Monitoring in CKD: A Report from the Chronic Renal Insufficiency Cohort (CRIC) Study.Journal of the American Society of Nephrology : JASN · 2020Observational
- Vascular α1-Adrenergic Receptor Responsiveness in Masked Hypertension.American journal of hypertension · 2020Article
- Current status of ambulatory blood pressure monitoring in Asian countries: A report from the HOPE Asia Network.Journal of clinical hypertension (Greenwich, Conn.) · 2020Review
- Sex differences in masked hypertension: the Coronary Artery Risk Development in Young Adults study.Journal of hypertension · 2019Article
- Masked Uncontrolled Hypertension Is Not Attributable to Medication Nonadherence.Hypertension (Dallas, Tex. : 1979) · 2019Article
- Impaired Autonomic Nervous System-Microbiome Circuit in Hypertension.Circulation research · 2019Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Masked uncontrolled hypertension (MUCH) is defined as controlled automated office blood pressure (BP; AOBP <135/85 mm Hg) in-clinic in patients receiving antihypertensive medication(s) but uncontrolled BP out-of-clinic by 24-hour ambulatory BP monitoring (ABPM; awake ≥135/85 mm Hg). We hypothesized that MUCH patients have greater out-of-clinic sympathetic activity compared with true controlled hypertensives. Patients being treated for hypertension were prospectively recruited after 3 or more consecutive clinic visits. All patients were evaluated by in-clinic automated office BP, plasma catecholamines, and spot-urine/plasma metanephrines. In addition, out-of-clinic 24-hour ABPM, 24-hour urinary for catecholamines and metanephrines was done. Out of 237 patients recruited, 169 patients had controlled in-clinic BP of which 156 patients had completed ABPM. Seventy-four were true controlled hypertensives, that is controlled by clinic automated office BP and by out-of-clinic ABPM. The remaining 82 were controlled by clinic automated office BP, but uncontrolled during out-of-clinic ABPM, indicative of MUCH. After exclusion of 4 patients because of inadequate or lack of 24-hour urinary collections, 72 true controlled hypertensive and 80 MUCH patients were analyzed. MUCH patients had significantly higher out-of-clinic BP variability and lower heart rate variability compared with true controlled hypertensives, as well as higher levels of out-of-clinic urinary catecholamines and metanephrines levels consistent with higher out-of-clinic sympathetic activity. In contrast, there was no difference in in-clinic plasma catecholamines and spot-urine/plasma levels of metanephrines between the 2 groups, consistent with similar levels of sympathetic activity while in clinic. MUCH patients have evidence of heightened out-of-clinic sympathetic activity compared with true controlled hypertensives, which may contribute to the development of MUCH.
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Registered trials
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