ArticleJournal of the American Heart Association2018
Metabolites Associated With the Risk of Incident Venous Thromboembolism: A Metabolomic Analysis.
Article in Journal of the American Heart Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Mendelian randomization identifies causal effects of phospholipids on portal vein thrombosis risk: FADS1/2-mediated pathways and their potential as diagnostic biomarkers.Nutrition & metabolism · 2026Article
- Accessing Altered Metabolic Profile in Acute Deep Vein Thrombosis Through Nuclear Magnetic Resonance Spectroscopy.International journal of molecular sciences · 2025Article
- Diagnosis of deep vein thrombosis from γ-butylbetaine and L-carnitine in plasma and urine based on untargeted and targeted metabolomics.Scientific reports · 2025Article
- Review
- Integrated landscape of plasma metabolism and proteome of patients with post-traumatic deep vein thrombosis.Nature communications · 2024Article
- Two-sample Mendelian randomization analysis reveals causal relationships between blood lipids and venous thromboembolism.Haematologica · 2024Article
- Metabolomic profiling of deep vein thrombosis.Phlebology · 2024Review
- Acute venous thromboembolism plasma and red blood cell metabolomic profiling reveals potential new early diagnostic biomarkers: observational clinical study.Journal of translational medicine · 2024Observational
- Potential causal relationships between blood metabolites, inflammatory cytokines, and venous thromboembolism.Frontiers in immunology · 2024Article
- The admission pH is a risk factor of preoperative deep vein thrombosis in geriatric hip fracture: a retrospective cohort study.Scientific reports · 2023Article
- Metabolomic epidemiology offers insights into disease aetiology.Nature metabolism · 2023Review
- The Role of Biomarkers, Metabolomics, and COVID-19 in Venous Thromboembolism-A Review of Literature.International journal of molecular sciences · 2023Review
- A metabolome-wide association study of in utero metal and trace element exposures with cord blood metabolome profile: Findings from the Boston Birth Cohort.Environment international · 2022Article
- Article
- Metabolomic Profile in Venous Thromboembolism (VTE).Metabolites · 2021Review
- Predicting the Risk of Recurrent Venous Thromboembolism: Current Challenges and Future Opportunities.Journal of clinical medicine · 2020Review
- Metabolome-Wide Association Study of the Relationship Between Habitual Physical Activity and Plasma Metabolite Levels.American journal of epidemiology · 2019Article
- Metabolomics Analytics Workflow for Epidemiological Research: Perspectives from the Consortium of Metabolomics Studies (COMETS).Metabolites · 2019Article
- Metabolites Associated With the Risk of Incident Venous Thromboembolism: A Metabolomic Analysis.Journal of the American Heart Association · 2018Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
Background Venous thromboembolism ( VTE ) is a complex thrombotic disorder that constitutes a major source of mortality and morbidity. To improve understanding of the cause of VTE , we conducted a metabolomic analysis in a case-control study including 240 incident VTE cases and 6963 controls nested within 3 large prospective population-based cohorts, the Nurses' Health Study, the Nurses' Health Study II , and the Health Professionals Follow-Up Study. Methods and Results For each individual, we measured 211 metabolites and collected detailed information on lifestyle factors. We performed logistic regression and enrichment analysis to identify metabolites and biological categories associated with incident VTE risk, accounting for key confounders, such as age, sex, smoking, alcohol consumption, body mass index, and comorbid diseases (eg, cancers). We performed analyses of all VTEs and separate analyses of pulmonary embolism. Using the basic model controlling for age, sex, and primary disease, we identified 60 nominally significant VTE - or pulmonary embolism-associated metabolites ( P<0.05). These metabolites were enriched for diacylglycerols ( P
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.