Evidence map›Paper›PMID 30571483›Full record

ArticleJournal of the American Heart Association2018

Relationship Between Electrocardiographic Findings and Cardiac Magnetic Resonance Phenotypes in Arrhythmogenic Cardiomyopathy.

Manuel De Lazzari, Alessandro Zorzi, Alberto Cipriani, Angela Susana, Giulio Mastella, Alessandro Rizzo, Ilaria Rigato, Barbara Bauce, Benedetta Giorgi, Carmelo Lacognata and 3 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 76 citations in OpenAlex.

  1. Article
  2. The diagnostic value of electrocardiogram in the left variants of desmosomal arrhythmogenic cardiomyopathy.European heart journal supplements : journal of the European Society of Cardiology · 2025
    Article
  3. Athlete's ECG Made Easy: A Practical Guide to Surviving Everyday Clinical Practice.Journal of cardiovascular development and disease · 2024
    Review
  4. Review
  5. Genetic background determines the severity of age-dependent cardiac structural abnormalities and arrhythmia susceptibility in Scn5a-1798insD mice.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024
    Article
  6. Review
  7. Article
  8. Review
  9. Pragmatic electrocardiogram tracings in non-ischaemic dilated cardiomyopathy: diagnostic and prognostic role.European heart journal supplements : journal of the European Society of Cardiology · 2023
    Article
  10. The value of the 12-lead electrocardiogram in the prediction of sudden cardiac death.European heart journal supplements : journal of the European Society of Cardiology · 2023
    Article
  11. Electrocardiographic findings in patients with arrhythmogenic cardiomyopathy and right bundle branch block ventricular tachycardia.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023
    Article
  12. Review
  13. The Many Faces of Arrhythmogenic Cardiomyopathy: An Overview.The application of clinical genetics · 2023
    Review
  14. The pivotal role of ECG in cardiomyopathies.Frontiers in cardiovascular medicine · 2023
    Review
  15. Article
  16. Certainties and Uncertainties of Cardiac Magnetic Resonance Imaging in Athletes.Journal of cardiovascular development and disease · 2022
    Review
  17. Prevalence and clinical significance of isolated low QRS voltages in young athletes.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2022
    Article
  18. Review
  19. Article
  20. Arrhythmogenic left ventricular cardiomyopathy.Heart (British Cardiac Society) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Manuel De Lazzari1 Department of Cardiac, Thoracic and Vascular Sciences University of Padova Italy.
Alessandro Zorzi1 Department of Cardiac, Thoracic and Vascular Sciences University of Padova Italy.
Alberto Cipriani1 Department of Cardiac, Thoracic and Vascular Sciences University of Padova Italy.
Angela Susana1 Department of Cardiac, Thoracic and Vascular Sciences University of Padova Italy.
Giulio Mastella1 Department of Cardiac, Thoracic and Vascular Sciences University of Padova Italy.
Alessandro Rizzo1 Department of Cardiac, Thoracic and Vascular Sciences University of Padova Italy.
Ilaria Rigato1 Department of Cardiac, Thoracic and Vascular Sciences University of Padova Italy.
Barbara Bauce1 Department of Cardiac, Thoracic and Vascular Sciences University of Padova Italy.
Benedetta Giorgi2 Division of Radiology Department of Medicine University of Padova Italy.
Carmelo Lacognata2 Division of Radiology Department of Medicine University of Padova Italy.
Sabino Iliceto1 Department of Cardiac, Thoracic and Vascular Sciences University of Padova Italy.
Domenico Corrado1 Department of Cardiac, Thoracic and Vascular Sciences University of Padova Italy.
Martina Perazzolo Marra1 Department of Cardiac, Thoracic and Vascular Sciences University of Padova Italy.
University of Padua · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background The new designation of arrhythmogenic cardiomyopathy defines a broader spectrum of disease phenotypes, which include right dominant, biventricular, and left dominant variants. We evaluated the relationship between electrocardiographic findings and contrast-enhanced cardiac magnetic resonance phenotypes in arrhythmogenic cardiomyopathy. Methods and Results We studied a consecutive cohort of patients with a definite diagnosis of arrhythmogenic cardiomyopathy, according to 2010 International Task Force criteria, who underwent electrocardiography and contrast-enhanced cardiac magnetic resonance. Both depolarization and repolarization electrocardiographic abnormalities were correlated with the severity of dilatation/dysfunction, either global or regional, of both ventricles and the presence and regional distribution of late gadolinium enhancement. The study population included 79 patients (60% men). There was a statistically significant relationship between the presence and extent of T-wave inversion across a 12-lead ECG and increasing values of median right ventricular ( RV ) end-diastolic volume ( P<0.001) and decreasing values of RV ejection fraction ( P<0.001). The extent of T-wave inversion to lateral leads predicted a more severe RV dilatation rather than a left ventricular involvement because of the leftward displacement of the dilated RV , as evidenced by contrast-enhanced cardiac magnetic resonance. A terminal activation delay of >55 ms in the right precordial leads (V1-V3) was associated with higher RV volume ( P=0.014) and lower RV ejection fraction ( P=0.053). Low QRS voltages in limb leads predicted the presence ( P=0.004) and amount ( P<0.001) of left ventricular late gadolinium enhancement. Conclusions The study results indicated that electrocardiographic abnormalities predict the arrhythmogenic cardiomyopathy phenotype in terms of severity of RV disease and left ventricular involvement, which are among the most important determinants of the disease outcome.

Indexed as

ElectrocardiographyMagnetic Resonance ImagingAdultArrhythmogenic Right Ventricular DysplasiaFemaleHeart VentriclesHumansMaleMiddle AgedPhenotypeSeverity of Illness IndexYoung Adultcardiac magnetic resonance imagingcardiomyopathyelectrocardiographylate gadolinium enhancement

Identifiers

PMID30571483
PMCPMC6404435
OpenAlexW2901453076

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.