Evidence map›Paper›PMID 30571460›Full record

ArticleCirculation research2018

Macrophage Inflammation, Erythrophagocytosis, and Accelerated Atherosclerosis in Jak2

Wei Wang, Wenli Liu, Trevor Fidler, Ying Wang, Yang Tang, Brittany Woods, Carrie Welch, Bishuang Cai, Carlos Silvestre-Roig, Ding Ai and 7 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 170 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
170citing papers in PubMed, 1 pooled it
11.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

170 citing papers in PubMed, 1 synthesis or guideline pooled it, 248 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Arteriosclerosis, thrombosis, and vascular biology · 2026
    Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Distinct types of regulated cell death in atherosclerosis.Journal of pharmaceutical analysis · 2026
    Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Review
  18. Clonal Hematopoiesis and Cardiovascular Outcomes in Older Women.Journal of the American College of Cardiology · 2025
    Article
  19. Article
  20. Article

110 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 5 countries.

Wei WangFrom the Division of Molecular Medicine, Department of Medicine (W.W., W.L., T.F., Y.W., Y.T., C.W., B.C., I.T., A.R.T., N.W.), Columbia University Medical Center, New York, NY.
Wenli LiuFrom the Division of Molecular Medicine, Department of Medicine (W.W., W.L., T.F., Y.W., Y.T., C.W., B.C., I.T., A.R.T., N.W.), Columbia University Medical Center, New York, NY.
Trevor FidlerFrom the Division of Molecular Medicine, Department of Medicine (W.W., W.L., T.F., Y.W., Y.T., C.W., B.C., I.T., A.R.T., N.W.), Columbia University Medical Center, New York, NY.
Ying WangFrom the Division of Molecular Medicine, Department of Medicine (W.W., W.L., T.F., Y.W., Y.T., C.W., B.C., I.T., A.R.T., N.W.), Columbia University Medical Center, New York, NY.
Yang TangFrom the Division of Molecular Medicine, Department of Medicine (W.W., W.L., T.F., Y.W., Y.T., C.W., B.C., I.T., A.R.T., N.W.), Columbia University Medical Center, New York, NY.
Brittany WoodsHuman Oncology and Pathogenesis Program (B.W., R.L.L.), Memorial Sloan Kettering Cancer Center, New York, NY.
Carrie WelchFrom the Division of Molecular Medicine, Department of Medicine (W.W., W.L., T.F., Y.W., Y.T., C.W., B.C., I.T., A.R.T., N.W.), Columbia University Medical Center, New York, NY.
Bishuang CaiFrom the Division of Molecular Medicine, Department of Medicine (W.W., W.L., T.F., Y.W., Y.T., C.W., B.C., I.T., A.R.T., N.W.), Columbia University Medical Center, New York, NY.
Carlos Silvestre-RoigInstitute for Cardiovascular Prevention, Ludwig-Maximilians-University, Munich, Germany (C.S.-R., A.H., O.S.).
Ding AiTianjin Key Laboratory of Metabolic Diseases, Department of Physiology and Pathophysiology, Tianjin Medical University, China (W.L., D.A.).
Yong-Guang YangColumbia Center for Translational Immunology (Y.-G.Y.), Columbia University Medical Center, New York, NY.
Andres HidalgoInstitute for Cardiovascular Prevention, Ludwig-Maximilians-University, Munich, Germany (C.S.-R., A.H., O.S.).
Oliver SoehnleinInstitute for Cardiovascular Prevention, Ludwig-Maximilians-University, Munich, Germany (C.S.-R., A.H., O.S.).
Ira TabasFrom the Division of Molecular Medicine, Department of Medicine (W.W., W.L., T.F., Y.W., Y.T., C.W., B.C., I.T., A.R.T., N.W.), Columbia University Medical Center, New York, NY.
Ross L LevineHuman Oncology and Pathogenesis Program (B.W., R.L.L.), Memorial Sloan Kettering Cancer Center, New York, NY.
Alan R TallFrom the Division of Molecular Medicine, Department of Medicine (W.W., W.L., T.F., Y.W., Y.T., C.W., B.C., I.T., A.R.T., N.W.), Columbia University Medical Center, New York, NY.
Nan WangFrom the Division of Molecular Medicine, Department of Medicine (W.W., W.L., T.F., Y.W., Y.T., C.W., B.C., I.T., A.R.T., N.W.), Columbia University Medical Center, New York, NY.
Columbia University Irving Medical Center · USLudwig-Maximilians-Universität München · DEMemorial Sloan Kettering Cancer Center · USSpanish National Centre for Cardiovascular Research · ESTianjin Medical University · CN

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Translational Biomarker Analytical Core (TBAC)P30DK063608 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DOMENICO ACCILI · 2003 to 2026
$36.7M
NRSA Training CoreTL1TR001875 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SPANN, MARISA N, TAYLOR, JACQUELYN Y · 2016 to 2025
$8.9M
Cholesterol efflux, CHIP and inflammasome activationR01HL107653 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ALAN richard TALL · 2011 to 2026
$7.7M
HDL, platelet progenitors, atherosclerosis and thrombosisR01HL118567 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WANG, NAN · 2014 to 2018
$2.0M
BD Biosciences InfluxS10OD020056 · OD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SNOECK, HANS-WILLEM E · 2015 to 2015
$600k
Becton Dickinson LSR II Analytical Flow CytometerS10RR027050 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CLYNES, RAPHAEL A. · 2011 to 2011
$413k
MerTK in NASH-related liver fibrosisK99DK115778 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CAI, BISHUANG · 2018 to 2019
$178k
NCATS NIH HHS TL1 TR001875NCI NIH HHS P30 CA008748NCRR NIH HHS S10 RR027050NHLBI NIH HHS R01 HL107653NHLBI NIH HHS R01 HL118567NIDDK NIH HHS K99 DK115778NIDDK NIH HHS P30 DK063608NIH HHS S10 OD020056
6 · The paper itself

Abstract

rationaleThe mechanisms driving atherothrombotic risk in individuals with JAK2

objectiveThe goal of this study was to assess atherosclerosis and underlying mechanisms in hypercholesterolemic mice with hematopoietic Jak2 METHODS AND

resultsIrradiated low-density lipoprotein receptor knockout ( Ldlr

conclusionsHematopoietic Jak2

Indexed as

PhagocytosisAdultAgedAnimalsAtherosclerosisCD47 Antigenc-Mer Tyrosine KinaseCytokinesErythrocytesFemaleHematopoiesisHumansIronJanus Kinase 2MacrophagesMaleCD47 Antigenc-Mer Tyrosine KinaseCytokinesIronJak2 protein, mouseJanus Kinase 2p38 Mitogen-Activated Protein Kinasesatherosclerosiserythrocytesinflammasomesinflammationmacrophages

Identifiers

PMID30571460
PMCPMC6309796
OpenAlexW2891613655

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.