Evidence map›Paper›PMID 30571425›Full record

ArticleStroke2018

Validation of the Intracerebral Hemorrhage Score in Uganda.

Amir Abdallah, Jonathan L Chang, Cumara B O'Carroll, Samson Okello, Sam Olum, Moses Acan, Abdirahim Abdi Aden, Felicia C Chow, Mark J Siedner

Abstract readValidation Study
In one paragraph

Article in Stroke, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Amir AbdallahFrom the Department of Medicine (A.A., S.O., A.A.A., M.J.S.), Mbarara University of Science and Technology, Uganda.
Jonathan L ChangDuke University School of Medicine, Durham, NC (J.L.C.).
Cumara B O'CarrollDepartment of Neurology, Mayo Clinic, Arizona (C.B.O.).
Samson OkelloDepartment of Medicine, Gulu University, Uganda (S.O.).
Sam OlumFrom the Department of Medicine (A.A., S.O., A.A.A., M.J.S.), Mbarara University of Science and Technology, Uganda.
Moses AcanDepartment of Radiology (M.A.), Mbarara University of Science and Technology, Uganda.
Abdirahim Abdi AdenFrom the Department of Medicine (A.A., S.O., A.A.A., M.J.S.), Mbarara University of Science and Technology, Uganda.
Felicia C ChowDepartment of Neurology, UCSF School of Medicine, CA (F.C.C.).
Mark J SiednerFrom the Department of Medicine (A.A., S.O., A.A.A., M.J.S.), Mbarara University of Science and Technology, Uganda.

Funding

The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI ROBERT A. PARKER · 2004 to 2026
$94.4M
Mbarara University Research Training Initiative (MURTI)D43TW010128 · FIC · MBARARA UNIVERSITY/SCIENCE/ TECHNOLOGY · PI OBUA, CELESTINO · 2015 to 2019
$3.5M
Behavioral Aspects of Low-cost Medical Devices to Improve HIV CareK23MH099916 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI SIEDNER, MARK J · 2013 to 2017
$917k
Polycyclic aromatic hydrocarbons exposure and dietary risk of Esophageal squamous cell carcinoma in UgandaK43TW010715 · FIC · MBARARA UNIVERSITY/SCIENCE/ TECHNOLOGY · PI OKELLO, SAMSON · 2017 to 2021
$456k
FIC NIH HHS D43 TW010128FIC NIH HHS K43 TW010715NIAID NIH HHS P30 AI060354NIMH NIH HHS K23 MH099916
6 · The paper itself

Abstract

Background and Purpose- Rates of intracerebral hemorrhage (ICH) are estimated to be highest globally in sub-Saharan Africa. However, outcomes of ICH are poorly described and standard prognostic markers for ICH have not been validated in the region. Methods- We enrolled consecutive patients with computed tomography-confirmed ICH at a referral hospital in southwestern Uganda. We recorded demographic, clinical, and radiographic features of ICH, and calculated ICH scores. We fit Poisson regression models with robust variance estimation to determine predictors of case fatality at 30 days. Results- We enrolled 73 individuals presenting with computed tomography-confirmed ICH (mean age 60 years, 45% [33/73] female, and 14% [10/73] HIV-positive). The median ICH score was 2 (interquartile range, 1-3; range, 0-5). Case fatality at 30 days was 44% (32/73; 95% CI, 33%-57%). The 30-day case fatality increased with increasing ICH score of 0, 1, and 5 from 17%, 23%, to 100%, respectively. In multivariable-adjusted models, ICH score was associated with case fatality (adjusted relative risk, 1.48; 95% CI, 1.23-1.78), as were HIV infection (adjusted relative risk, 1.92; 95% CI, 1.07-3.43) and female sex (adjusted relative risk, 2.17; 95% CI, 1.32-3.59). The ICH score moderately improved with the addition of a point each for female sex and HIV serostatus (0.81 versus 0.73). Conclusions- ICH score at admission is a strong prognostic indicator of 30-day case fatality in Uganda. Our results support its role in guiding the care of patients presenting with ICH in the region.

Indexed as

Glasgow Coma ScaleAdultAgedAged, 80 and overAge FactorsCerebral HemorrhageCohort StudiesComorbidityFemaleHematomaHIV InfectionsHumansMaleMiddle AgedMultivariate AnalysisPoisson Distributioncerebral hemorrhageHIV infectionsmortalitysexstrokeUganda

Identifiers

PMID30571425
PMCPMC6309793

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.