GuidelineCirculation2018
2018 American Heart Association Focused Update on Advanced Cardiovascular Life Support Use of Antiarrhythmic Drugs During and Immediately After Cardiac Arrest: An Update to the American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care.
Guideline in Circulation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
64 citing papers in PubMed, 7 syntheses or guidelines pooled it, 184 citations in OpenAlex.
- Intraosseous versus intravenous vascular access during out-of-hospital cardiac arrest: a systematic review and meta-analysis.Proceedings (Baylor University. Medical Center) · 2026Pooled it
- Antiarrhythmic drugs for cardiac arrest with a shockable rhythm and their effect on outcomes: a systematic review with meta-analysis.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025Pooled it
- Efficacy of intraosseous access for trauma resuscitation: a systematic review and meta-analysis.World journal of emergency surgery : WJES · 2023Pooled it
- Comparing Drugs for Out-of-hospital, Shock-refractory Cardiac Arrest: Systematic Review and Network Meta-analysis of Randomized Controlled Trials.The western journal of emergency medicine · 2021Pooled it
- 2020 Korean Guidelines for Cardiopulmonary Resuscitation. Part 4. Adult advanced life support.Clinical and experimental emergency medicine · 2021Guideline
- Intraosseous versus intravenous vascular access during cardiopulmonary resuscitation for out-of-hospital cardiac arrest: a systematic review and meta-analysis of observational studies.Scandinavian journal of trauma, resuscitation and emergency medicine · 2021Pooled it
- Recommendations for initial examination, differential diagnosis, and management of concussion and other head injuries in high-level football.Scandinavian journal of medicine & science in sports · 2020Guideline
- Prediction of Shock-Refractory Ventricular Fibrillation During Resuscitation of Out-of-Hospital Cardiac Arrest.Circulation · 2023Trial
- Effect of Time to Treatment With Antiarrhythmic Drugs on Return of Spontaneous Circulation in Shock-Refractory Out-of-Hospital Cardiac Arrest.Journal of the American Heart Association · 2022Trial
- Cardiac α4β2 nicotinic receptors as a therapeutic target for fatal ventricular arrhythmias.European heart journal · 2026Article
- Comparative Effectiveness of Amiodarone Versus Lidocaine as Antiarrhythmic Therapy for Cardiac Arrest with Shockable Rhythms: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Review
- Esmolol in the management of refractory ventricular fibrillation: a systematic review and meta-analysis.Acute and critical care · 2026Article
- [Emergency pharmacotherapy in rhythmology].Herzschrittmachertherapie & Elektrophysiologie · 2026Review
- Risk assessment for cardiovascular adverse drug events in the ICU: Case study on COVID-19 patients.PloS one · 2026Article
- Ghana Heart Initiative Training for Cardiac Arrest Management Among Health Care Professionals: Outcomes Evaluation Study (2019-2024).JMIR formative research · 2025Article
- Factors associated with shock-refractory prehospital cardiac arrest.Scientific reports · 2025Observational
- Practical compendium of antiarrhythmic drugs: a clinical consensus statement of the European Heart Rhythm Association of the European Society of Cardiology.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025Review
- A retrospective 'target trial emulation' comparing amiodarone and lidocaine for adult out-of-hospital cardiac arrest resuscitation.Resuscitation · 2025Article
- Dorsal penile nerve block complicated by local anaesthetic systemic toxicity.Urology case reports · 2025Article
- Management of Patients With Cardiac Arrest Requiring Interfacility Transport: A Scientific Statement From the American Heart Association.Circulation · 2024Review
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 3 countries.
Funding
Abstract
Antiarrhythmic medications are commonly administered during and immediately after a ventricular fibrillation/pulseless ventricular tachycardia cardiac arrest. However, it is unclear whether these medications improve patient outcomes. This 2018 American Heart Association focused update on advanced cardiovascular life support guidelines summarizes the most recent published evidence for and recommendations on the use of antiarrhythmic drugs during and immediately after shock-refractory ventricular fibrillation/pulseless ventricular tachycardia cardiac arrest. This article includes the revised recommendation that providers may consider either amiodarone or lidocaine to treat shock-refractory ventricular fibrillation/pulseless ventricular tachycardia cardiac arrest.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.