Evidence map›Paper›PMID 30571224›Full record

ArticleHypertension (Dallas, Tex. : 1979)2018

Proximal Tubule-Specific Deletion of the NHE3 (Na

Xiao C Li, Manoocher Soleimani, Dongmin Zhu, Isabelle Rubera, Michel Tauc, Xiaowen Zheng, Jianfeng Zhang, Xu Chen, Jia L Zhuo

Open access · bronzeAbstract read
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 55 citations in OpenAlex.

  1. Article
  2. Review
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  5. Article
  6. Article
  7. A key role of ATAmerican journal of physiology. Renal physiology · 2025
    Article
  8. Histamine regulates the activity and the expression of the NaInflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
    Article
  9. Gliflozins in hypertension: basic mechanisms and clinical insights.American journal of physiology. Renal physiology · 2025
    Review
  10. Article
  11. Review
  12. Incretin and glucagon receptor polypharmacology in chronic kidney disease.American journal of physiology. Endocrinology and metabolism · 2024
    Review
  13. Article
  14. New functions and roles of the NaPflugers Archiv : European journal of physiology · 2024
    Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Frontiers in pharmacology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Xiao C LiFrom the Division of Nephrology, Department of Pharmacology and Toxicology and Department of Medicine, University of Mississippi Medical Center, Jackson (X.C.L., X.Z., J.Z., X.C., J.L.Z.).
Manoocher SoleimaniDivision of Nephrology and Hypertension, Department of Internal Medicine, The University of Cincinnati College of Medicine, OH (M.S.).
Dongmin ZhuDepartment of Outpatients, Guangxi Science and Technology University No. 1 Affiliated Hospital, Liuzhou, China (D.Z.).
Isabelle RuberaLaboratoire Centre National de la Recherche Scientifique (CNRS) 3472 LP2M, Université de Nice Sophia Antipolis, Nice Cedex 2, France (I.R., M.T.).
Michel TaucLaboratoire Centre National de la Recherche Scientifique (CNRS) 3472 LP2M, Université de Nice Sophia Antipolis, Nice Cedex 2, France (I.R., M.T.).
Xiaowen ZhengFrom the Division of Nephrology, Department of Pharmacology and Toxicology and Department of Medicine, University of Mississippi Medical Center, Jackson (X.C.L., X.Z., J.Z., X.C., J.L.Z.).
Jianfeng ZhangFrom the Division of Nephrology, Department of Pharmacology and Toxicology and Department of Medicine, University of Mississippi Medical Center, Jackson (X.C.L., X.Z., J.Z., X.C., J.L.Z.).
Xu ChenFrom the Division of Nephrology, Department of Pharmacology and Toxicology and Department of Medicine, University of Mississippi Medical Center, Jackson (X.C.L., X.Z., J.Z., X.C., J.L.Z.).
Jia L ZhuoFrom the Division of Nephrology, Department of Pharmacology and Toxicology and Department of Medicine, University of Mississippi Medical Center, Jackson (X.C.L., X.Z., J.Z., X.C., J.L.Z.).
University of Mississippi Medical Center · USCentre National de la Recherche Scientifique · FRGuangxi University of Science and Technology · CNUniversité Côte d'Azur · FRUniversity of Cincinnati Medical Center · US

Funding

Role of Intracrine Angiotensin II in Kidney CellsR01DK067299 · NIDDK · UNIVERSITY OF MISSISSIPPI MED CTR · PI Jia Long Zhuo · 2004 to 2026
$6.5M
Gender and susceptibility to kidney damage in high BP.R01HL069194 · NHLBI · UNIVERSITY OF MISSISSIPPI MEDICAL CENTER · PI RECKELHOFF, JANE F · 2001 to 2010
$2.5M
Role of Proximal Tubule NHE3 in Angiotensin II-induced HypertensionR01DK102429 · NIDDK · UNIVERSITY OF MISSISSIPPI MED CTR · PI ZHUO, JIA LONG · 2014 to 2021
$2.5M
The Na+/H+ Exchanger 3, Pressure Natriuresis, and HypertensionR56HL130988 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI ZHUO, JIA LONG · 2016 to 2016
$381k
Novel Roles of Intracrine Angiotensin II in Proximal Tubule CellsR56DK067299 · NIDDK · HENRY FORD HEALTH SYSTEM · PI ZHUO, JIA LONG · 2009 to 2009
$352k
BLRD VA I01 BX001000NHLBI NIH HHS R01 HL069194NHLBI NIH HHS R56 HL130988NIDDK NIH HHS R01 DK067299NIDDK NIH HHS R01 DK102429NIDDK NIH HHS R56 DK067299
6 · The paper itself

Abstract

The present study directly tested the hypothesis that deletion of the NHE3 (Na

Indexed as

AnimalsBlood PressureKidneyKidney Tubules, ProximalMiceMice, KnockoutNatriuresisSodium Chloride, DietarySodium-Hydrogen Exchanger 3Slc9a3 protein, mouseSodium Chloride, DietarySodium-Hydrogen Exchanger 3blood pressurehypertensionkidneymicenatriuresis

Identifiers

PMID30571224
PMCPMC6309803
OpenAlexW2895506048

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.