Evidence map›Paper›PMID 30571174›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2018

Ablation of Myeloid ADK (Adenosine Kinase) Epigenetically Suppresses Atherosclerosis in ApoE

Min Zhang, Xianqiu Zeng, Qiuhua Yang, Jiean Xu, Zhiping Liu, Yaqi Zhou, Yapeng Cao, Xiaoyu Zhang, Xiaofei An, Yiming Xu and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Adenosine Kinase: An Epigenetic Modulator and Drug Target.Journal of inherited metabolic disease · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Annual Report on Sex in Preclinical Studies:Arteriosclerosis, thrombosis, and vascular biology · 2020
    Review
  18. Article
  19. Updates on Approaches for Studying Atherosclerosis.Arteriosclerosis, thrombosis, and vascular biology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 2 countries.

Min ZhangFrom the Key Laboratory of Chemical Genomics, State Key Laboratory of Chemical Oncogenomics, Drug Discovery Center, Peking University Shenzhen Graduate School, China (M.Z., X.Z., Q.Y., J.X., Z.L., Y.Z., Y.C., X.Z., M.H.).
Xianqiu ZengFrom the Key Laboratory of Chemical Genomics, State Key Laboratory of Chemical Oncogenomics, Drug Discovery Center, Peking University Shenzhen Graduate School, China (M.Z., X.Z., Q.Y., J.X., Z.L., Y.Z., Y.C., X.Z., M.H.).
Qiuhua YangFrom the Key Laboratory of Chemical Genomics, State Key Laboratory of Chemical Oncogenomics, Drug Discovery Center, Peking University Shenzhen Graduate School, China (M.Z., X.Z., Q.Y., J.X., Z.L., Y.Z., Y.C., X.Z., M.H.).
Jiean XuFrom the Key Laboratory of Chemical Genomics, State Key Laboratory of Chemical Oncogenomics, Drug Discovery Center, Peking University Shenzhen Graduate School, China (M.Z., X.Z., Q.Y., J.X., Z.L., Y.Z., Y.C., X.Z., M.H.).
Zhiping LiuFrom the Key Laboratory of Chemical Genomics, State Key Laboratory of Chemical Oncogenomics, Drug Discovery Center, Peking University Shenzhen Graduate School, China (M.Z., X.Z., Q.Y., J.X., Z.L., Y.Z., Y.C., X.Z., M.H.).
Yaqi ZhouFrom the Key Laboratory of Chemical Genomics, State Key Laboratory of Chemical Oncogenomics, Drug Discovery Center, Peking University Shenzhen Graduate School, China (M.Z., X.Z., Q.Y., J.X., Z.L., Y.Z., Y.C., X.Z., M.H.).
Yapeng CaoFrom the Key Laboratory of Chemical Genomics, State Key Laboratory of Chemical Oncogenomics, Drug Discovery Center, Peking University Shenzhen Graduate School, China (M.Z., X.Z., Q.Y., J.X., Z.L., Y.Z., Y.C., X.Z., M.H.).
Xiaoyu ZhangFrom the Key Laboratory of Chemical Genomics, State Key Laboratory of Chemical Oncogenomics, Drug Discovery Center, Peking University Shenzhen Graduate School, China (M.Z., X.Z., Q.Y., J.X., Z.L., Y.Z., Y.C., X.Z., M.H.).
Xiaofei AnVascular Biology Center, Medical College of Georgia, Augusta University, GA (X.Z., Q.Y., J.X., Z.L., Y.Z., X.A., Y.X., D.J.F., N.L.W., Y.H.).
Yiming XuVascular Biology Center, Medical College of Georgia, Augusta University, GA (X.Z., Q.Y., J.X., Z.L., Y.Z., X.A., Y.X., D.J.F., N.L.W., Y.H.).
Lei HuangDepartment of Cardiovascular Surgery, Peking University Shenzhen Hospital, China (L.H., Z.H., T.W.).
Zhen HanDepartment of Cardiovascular Surgery, Peking University Shenzhen Hospital, China (L.H., Z.H., T.W.).
Tao WangDepartment of Cardiovascular Surgery, Peking University Shenzhen Hospital, China (L.H., Z.H., T.W.).
Chaodong WuDepartment of Nutrition and Food Science, Texas A&M University, College Station, TX (C.W.).
David J FultonVascular Biology Center, Medical College of Georgia, Augusta University, GA (X.Z., Q.Y., J.X., Z.L., Y.Z., X.A., Y.X., D.J.F., N.L.W., Y.H.).
Neal L WeintraubVascular Biology Center, Medical College of Georgia, Augusta University, GA (X.Z., Q.Y., J.X., Z.L., Y.Z., X.A., Y.X., D.J.F., N.L.W., Y.H.).
Mei HongFrom the Key Laboratory of Chemical Genomics, State Key Laboratory of Chemical Oncogenomics, Drug Discovery Center, Peking University Shenzhen Graduate School, China (M.Z., X.Z., Q.Y., J.X., Z.L., Y.Z., Y.C., X.Z., M.H.).
Yuqing HuoVascular Biology Center, Medical College of Georgia, Augusta University, GA (X.Z., Q.Y., J.X., Z.L., Y.Z., X.A., Y.X., D.J.F., N.L.W., Y.H.).
Augusta University · USPeking University · CNPeking University Shenzhen Hospital · CNGuangzhou Medical University · CNTexas A&M University · US

Funding

Innovative Approaches to Treat Duchenne Muscular Dystrophy Using iPSC-Derived Muscle ProgenitorsR01AR070029 · NIAMS · AUGUSTA UNIVERSITY · PI ASHRAF, MUHAMMAD, TANG, YAO LIANG · 2016 to 2021
$2.6M
PFKFB3 in vascular remodelingR01HL134934 · NHLBI · AUGUSTA UNIVERSITY · PI HUO, YUQING, SU, YUNCHAO · 2017 to 2020
$2.3M
Mechanisms of myeloperoxidase and Nox4 interactions in abdominal aortic aneurysmR01HL142097 · NHLBI · AUGUSTA UNIVERSITY · PI WEINTRAUB, NEAL L · 2018 to 2021
$2.1M
Epigenetic regulation of HDAC9 in obesity and atherosclerosisR01HL126949 · NHLBI · AUGUSTA UNIVERSITY · PI WEINTRAUB, NEAL L · 2016 to 2019
$1.8M
Protective role of adenosine 2A receptor in NAFLDR01DK095862 · NIDDK · TEXAS A&M AGRILIFE RESEARCH · PI WU, CHAODONG · 2013 to 2017
$1.6M
The role of adenosine kinase in atherosclerosisR01HL095556 · NHLBI · UNIVERSITY OF MINNESOTA · PI HUO, YUQING · 2011 to 2015
$1.5M
NHLBI NIH HHS R01 HL095556NHLBI NIH HHS R01 HL126949NHLBI NIH HHS R01 HL134934NHLBI NIH HHS R01 HL142097NIAMS NIH HHS R01 AR070029NIDDK NIH HHS R01 DK095862
6 · The paper itself

Abstract

Objective- Monocyte-derived foam cells are one of the key players in the formation of atherosclerotic plaques. Adenosine receptors and extracellular adenosine have been demonstrated to modulate foam cell formation. ADK (adenosine kinase) is a major enzyme regulating intracellular adenosine levels, but its functional role in myeloid cells remains poorly understood. To enhance intracellular adenosine levels in myeloid cells, ADK was selectively deleted in novel transgenic mice using Cre-LoxP technology, and foam cell formation and the development of atherosclerotic lesions were determined. Approach and Results- ADK was upregulated in macrophages on ox-LDL (oxidized low-density lipoprotein) treatment in vitro and was highly expressed in foam cells in atherosclerotic plaques. Atherosclerotic mice deficient in ADK in myeloid cells were generated by breeding floxed ADK (ADK

Indexed as

Epigenesis, GeneticMice, Knockout, ApoEAdenosine KinaseAnimalsAortaAortic DiseasesAtherosclerosisATP Binding Cassette Transporter, Subfamily G, Member 1Cells, CulturedCholesterolDisease Models, AnimalDNA MethylationFemaleFoam CellsMaleMice, Inbred C57BLABCG1 protein, mouseAdenosine KinaseATP Binding Cassette Transporter, Subfamily G, Member 1Cholesterolatherosclerosischolesterol effluxfoam cellgene methylation

Identifiers

PMID30571174
PMCPMC6309817
OpenAlexW2903227793

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.