Evidence map›Paper›PMID 30571171›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2018

Time-Dependent Hypotensive Effect of Aspirin in Mice.

Lihong Chen, Guangrui Yang, Jiayang Zhang, Baoyin Ren, Soonyew Tang, Xuanwen Li, Garret A FitzGerald

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
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  5. Article
  6. Annual Report on Sex in Preclinical Studies:Arteriosclerosis, thrombosis, and vascular biology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Lihong ChenFrom the Advanced Institute for Medical Sciences, Dalian Medical University, China (L.C., J.Z.).
Guangrui YangSchool of Life Science and Biotechnology, Dalian University of Technology, China (G.Y., B.R.).
Jiayang ZhangFrom the Advanced Institute for Medical Sciences, Dalian Medical University, China (L.C., J.Z.).
Baoyin RenSchool of Life Science and Biotechnology, Dalian University of Technology, China (G.Y., B.R.).
Soonyew TangThe Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania (G.Y., S.T., X.L., G.A.F.).
Xuanwen LiThe Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania (G.Y., S.T., X.L., G.A.F.).
Garret A FitzGeraldThe Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania (G.Y., S.T., X.L., G.A.F.).
Dalian Medical University · CNDalian University of Technology · CNDalian University · CN

Funding

Pilot Study: POPULATION PHARMACOLOGYU54HL117798 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2012 to 2016
$18.5M
NHLBI NIH HHS U54 HL117798
6 · The paper itself

Abstract

Objective- Evening but not morning administration of low-dose aspirin has been reported to lower blood pressure in hypertensive patients. The present study was designed to determine whether this phenomenon could be replicated in mice, and if so, whether a time-dependent effect of aspirin on blood pressure was because of alteration of circadian clock function. Approach and Results- We recapitulated the protective effect of aspirin (50 μg/d for 7 days) at zeitgeber time 0 (active-to-rest transit), but not at zeitgeber time 12, on a high-salt diet-induced increase of blood pressure. However, the time of aspirin administration did not influence expression of canonical clock genes or their acetylation. We used mouse Bmal1 and Per2-luciferase reporters expressed in U2OS cells to determine the real-time effect of aspirin on circadian function but found that the oscillation of bioluminescence was unaltered. Timing of aspirin administration also failed to alter urinary prostaglandin metabolites or catecholamines, or the acetylation of its COX-1 (cyclooxygenase-1) target in platelets. Conclusions- The time-dependent hypotensive effect of aspirin in humans has been recapitulated in hypertensive mice. However, this does not seem to reflect a direct impact of aspirin on circadian clocks or on acetylation of platelet COX-1.

Indexed as

Circadian RhythmAnimalsAntihypertensive AgentsARNTL Transcription FactorsAspirinBlood PlateletsBlood PressureCell Line, TumorCircadian ClocksCyclooxygenase 1Disease Models, AnimalDrug ChronotherapyHumansHypertensionMaleMembrane ProteinsAntihypertensive AgentsARNTL Transcription FactorsAspirinBmal1 protein, mouseCyclooxygenase 1Membrane ProteinsPer2 protein, mousePeriod Circadian ProteinsPtgs1 protein, mouseSodium Chloride, Dietaryaspirinblood pressurecircadian clockmice

Identifiers

PMID30571171
PMCPMC6309345
OpenAlexW2896689790

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.