Evidence map›Paper›PMID 30570808›Full record

Observational studyLiver international : official journal of the International Association for the Study of the Liver2019

Sustained virological response does not improve long-term glycaemic control in patients with type 2 diabetes and chronic hepatitis C.

Jia Li, Stuart C Gordon, Loralee B Rupp, Talan Zhang, Sheri Trudeau, Scott D Holmberg, Anne C Moorman, Philip R Spradling, Eyasu H Teshale, Joseph A Boscarino and 4 more

Abstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Liver international : official journal of the International Association for the Study of the Liver, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  11. Over time evaluation of glycaemic control in direct-acting antiviral-treated hepatitis C virus/diabetic individuals with chronic hepatitis or with cirrhosis.Liver international : official journal of the International Association for the Study of the Liver · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jia LiDepartment of Public Health Sciences, Henry Ford Health System, Detroit, Michigan.ORCID 0000-0002-5931-3058
Stuart C GordonDivision of Gastroenterology and Hepatology, Henry Ford Health System and Wayne State University School of Medicine, Detroit, Michigan.
Loralee B RuppCenter for Health Policy and Health Services Research, Henry Ford Health System, Detroit, Michigan.
Talan ZhangDepartment of Public Health Sciences, Henry Ford Health System, Detroit, Michigan.
Sheri TrudeauDepartment of Public Health Sciences, Henry Ford Health System, Detroit, Michigan.
Scott D HolmbergDivision of Viral Hepatitis, National Center for HIV, Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.
Anne C MoormanDivision of Viral Hepatitis, National Center for HIV, Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.
Philip R SpradlingDivision of Viral Hepatitis, National Center for HIV, Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.
Eyasu H TeshaleDivision of Viral Hepatitis, National Center for HIV, Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.
Joseph A BoscarinoDepartment of Epidemiology & Health Services Research, Geisinger Clinic, Danville, Pennsylvania.
Mark A SchmidtCenter for Health Research, Kaiser Permanente-Northwest, Portland, Oregon.
Yihe G DaidaCenter for Health Research, Kaiser Permanente-Hawai'i, Honolulu, Hawaii.
Mei LuDepartment of Public Health Sciences, Henry Ford Health System, Detroit, Michigan.ORCID 0000-0002-3313-6428
CHeCS Investigators

Funding

Chronic Hepatitis Cohort Study–II (CHeCS–II)U18PS005154 · PS · HENRY FORD HEALTH SYSTEM · PI GORDON, STUART · 2016 to 2019
$1.4M
Intramural CDC HHS CC999999NCHHSTP CDC HHS U18 PS005154
6 · The paper itself

Abstract

backgroundSustained virological response to treatment for chronic hepatitis C virus may improve short-term glucose control among patients with type 2 diabetes, but the long-term impact remains largely unknown. We used data from the Chronic Hepatitis Cohort Study to investigate the impact of sustained virological response on long-term trends in haemoglobin A1c in patients with type 2 diabetes.

methods"Index date" was defined as the date of treatment initiation (treated patients) or hepatitis C virus diagnosis (untreated patients). To address treatment selection bias, we used a propensity score approach. We used a piecewise, linear spline, mixed-effects model to evaluate changes in haemoglobin A1c over a 5-year period.

resultsOur sample included 384 hepatitis C virus patients with type 2 diabetes (192 untreated, 192 treated, with sustained virological response or treatment failure). After adjusting for body mass index, haemoglobin A1c was stable among untreated and treatment failure patients. In sustained virological response patients, Hb1Ac trajectories evolved in three phases: (a) index through 6 months post-index, average haemoglobin A1c decreased significantly from 7.7% to 5.4% per 90 days (P < 0.001); (b) 6-30 months post-index, haemoglobin A1c rebounded at a rate of 1.5% every 90 days (P = 0.003); and (c) from 30 months onward, haemoglobin A1c stabilized at an average level of 7.9 (P-value = 0.34). Results from an analysis restricted to patients receiving direct-acting antivirals were consistent with the main findings.

conclusionSuccessful hepatitis C virus treatment among patients with type 2 diabetes significantly reduces HbA1c shortly after treatment, but these decreases are not sustained long-term. Less than three years after sustained virological response, haemoglobin A1c rebounds to levels similar to untreated/treatment failure patients, and higher than recommended for type 2 diabetic maintenance.

Indexed as

Sustained Virologic ResponseAgedAntiviral AgentsBlood GlucoseDiabetes Mellitus, Type 2FemaleGlycated HemoglobinHepacivirusHepatitis C, ChronicHumansLogistic ModelsMaleMiddle AgedProspective StudiesRetrospective StudiesTime FactorsAntiviral AgentsBlood GlucoseGlycated HemoglobinCHeCSdirect-acting antiviral DAAglycaemic controlhaemoglobin A1cinterferon

Identifiers

PMID30570808
PMCPMC6628708

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.