ArticleHuman brain mapping2019
Distinct roles of brain activity and somatotopic representation in pathophysiology of focal dystonia.
Article in Human brain mapping, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Spectrum of Dystonia in Spinocerebellar Ataxia.Tremor and other hyperkinetic movements (New York, N.Y.) · 2026Pooled it
- Cerebral Adaptation Associated with Peripheral Nerve Recovery in Neuralgic Amyotrophy: A Randomized Controlled Trial.Neurorehabilitation and neural repair · 2023Trial
- Botulinum Toxin Treatment in Musician's Dystonia: Long-Term-Effects and Influencing Factors.Toxins · 2026Article
- Quantification of Loudness Instability in Tone Production in Embouchure Dystonia.Journal of movement disorders · 2026Article
- Mapping the Neuroanatomy of Dystonia Using Causal Brain Lesions.medRxiv : the preprint server for health sciences · 2025Article
- Somato-Cognitive Action Network in Focal Dystonia.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Brain network pathophysiology in dystonia.Dystonia (Lausanne, Switzerland) · 2025Article
- Reliability and Validity of the Embouchure Dystonia Severity Rating Scale.Journal of movement disorders · 2023Article
- Intact finger representation within primary sensorimotor cortex of musician's dystonia.Brain : a journal of neurology · 2023Article
- Embouchure Dystonia as a Network Disease.Advances in neurobiology · 2023Article
- Impaired feedforward control of movements in pianists with focal dystonia.Frontiers in neurology · 2022Article
- De-anthropomorphizing brain mapping: How a "component" perspective unbounded by behavioral categories may reconcile localization vs. circuit-based models of brain function.Frontiers in systems neuroscience · 2022Article
- Altered Intrinsic Brain Activity in Patients With Toothache Using the Percent Amplitude of a Fluctuation Method: A Resting-State fMRI Study.Frontiers in neurology · 2022Article
- Structure-function abnormalities in cortical sensory projections in embouchure dystonia.NeuroImage. Clinical · 2020Article
- Neuropathology and pathogenesis of extrapyramidal movement disorders: a critical update. II. Hyperkinetic disorders.Journal of neural transmission (Vienna, Austria : 1996) · 2019Review
- Distinct roles of brain activity and somatotopic representation in pathophysiology of focal dystonia.Human brain mapping · 2019Article
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Authors and funding
6 authors.
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Abstract
Two main neural mechanisms including loss of cortical inhibition and maladaptive plasticity have been thought to be involved in the pathophysiology of focal task-specific dystonia. Such loss of inhibition and maladaptive plasticity likely correspond to cortical overactivity and disorganized somatotopy, respectively. However, the most plausible mechanism of focal task-specific dystonia remains unclear. To address this question, we assessed brain activity and somatotopic representations of motor-related brain areas using functional MRI and behavioral measurement in healthy instrumentalists and patients with embouchure dystonia as an example of focal task-specific dystonia. Dystonic symptoms were measured as variability of fundamental frequency during long tone playing. We found no significant differences in brain activity between the embouchure dystonia and healthy wind instrumentalists in the motor-related areas. Assessment of somatotopy, however, revealed significant differences in the somatotopic representations of the mouth area for the right somatosensory cortex between the two groups. Multiple-regression analysis revealed brain activity in the primary motor and somatosensory cortices, cerebellum, and putamen was significantly associated with variability of fundamental frequency signals representing dystonic symptoms. Conversely, somatotopic representations in motor-related brain areas were not associated with variability of fundamental frequency signals in embouchure dystonia. The present findings suggest that abnormal motor-related network activity and aberrant somatotopy correlate with different aspects of mechanisms underlying focal task-specific dystonia.
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