Evidence map›Paper›PMID 30570784›Full record

ArticleJournal of medical virology2019

Molecular epidemiology of noroviruses in children under 5 years of age with acute gastroenteritis in Yaoundé, Cameroon.

Akongnwi E Mugyia, Valentine N Ndze, Jane-Francis T K Akoachere, Hannah Browne, Angeline Boula, Paul Koki Ndombo, Jennifer L Cannon, Jan Vinjé, Lucy M Ndip

Abstract read
In one paragraph

Article in Journal of medical virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Homotypic and Heterotypic Protection and Risk of Reinfection Following Natural Norovirus Infection in a Highly Endemic Setting.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021
    Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Akongnwi E MugyiaDepartment of Microbiology and Parasitology, Faculty of Science, University of Buea, Buea, Cameroon.ORCID 0000-0001-6436-8670
Valentine N NdzeDepartment of Paediatrics, Faculty of Medicine and Biomedical Sciences, University of Yaoundé, Yaoundé, Cameroon.
Jane-Francis T K AkoachereDepartment of Microbiology and Parasitology, Faculty of Science, University of Buea, Buea, Cameroon.
Hannah BrowneOak Ridge Institute for Science and Education, Oak Ridge, Tennessee.
Angeline BoulaDeparment of Virology, Rotavirus National Reference Laboratory, Mother and Child Centre of the Chantal Biya Foundation, Yaoundé, Cameroon.
Paul Koki NdomboDepartment of Paediatrics, Faculty of Medicine and Biomedical Sciences, University of Yaoundé, Yaoundé, Cameroon.
Jennifer L CannonDepartment of Virology, CDC Foundation, Atlanta, Georgia.
Jan VinjéCenters for Disease Control and Prevention, Division of Viral Diseases, Atlanta, Georgia.
Lucy M NdipDepartment of Microbiology and Parasitology, Faculty of Science, University of Buea, Buea, Cameroon.

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

Norovirus is a common cause of acute gastroenteritis (AGE) among children in developing countries. Limited data on the prevalence and genetic variability of norovirus are available in Cameroon, where early childhood mortality due to AGE is common. We tested 902 fecal specimens from children younger than 5 years of age hospitalized with AGE between January 2010 and December 2013. Overall, 76 (8.4%) samples tested positive for norovirus, of which 83% (63/76) were among children below 12 months old. Most of the noroviruses detected were in children infected between July and December of each year. All norovirus-positive specimens were genotyped, with 80% (61/76) being GII.4 (three variants detected). Genotypes GI.2, GI.6, GII.1, GII.2, GII.3, GII.6, GII.16, GII.17, and GII.21 were also detected. Interestingly, GII.4 Sydney and GII.17 Kawasaki viruses were found as early as 2010, years before their emergence globally. This study suggests norovirus is a significant cause of moderate to severe gastroenteritis among young children in Cameroon. The results are important to highlight appropriate prevention and control strategies for reducing the burden of norovirus disease.

Indexed as

GenotypeCaliciviridae InfectionsCameroonChild, PreschoolFecesFemaleGastroenteritisHumansInfantInfant, NewbornMaleMolecular EpidemiologyNorovirusPrevalenceSeasonsacute gastroenteritis (AGE)Cameroongenotypesnorovirus

Identifiers

PMID30570784
PMCPMC8978256

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.