Evidence map›Paper›PMID 30570679›Full record

ArticleAnnals of intensive care2018

Nasal high-flow bronchodilator nebulization: a randomized cross-over study.

François Reminiac, Laurent Vecellio, Laetitia Bodet-Contentin, Valérie Gissot, Deborah Le Pennec, Charlotte Salmon Gandonnière, Maria Cabrera, Pierre-François Dequin, Laurent Plantier, Stephan Ehrmann

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of intensive care, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02812979 (Evaluation of the Effectiveness of the Nebulization Bronchodilators Under High Nasal Flow Humidified Compared to a Usual Method), which is not on this map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02812979 nacompletednot on this map

Evaluation of the Effectiveness of the Nebulization Bronchodilators Under High Nasal Flow Humidified Compared to a Usual Method

TypeinterventionalSponsorUniversity Hospital, ToursRan2016 to 2018Enrolled25ConditionsChronic Obstructive Pulmonary DiseaseArmsAirvo2 with Aerogen Solo, Mask, arm control Airvo2 without nebulization of salbutamol
3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Short-acting βInternal medicine (Tokyo, Japan) · 2025
    Article
  5. Nebuliser therapy in critical care: The past, present and future.Journal of the Intensive Care Society · 2024
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Nasal high-flow oxygenERJ open research · 2020
    Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

François ReminiacMédecine Intensive Réanimation, CHRU de Tours, 2, Bd Tonnellé, 37044, Tours Cedex 9, France.
Laurent VecellioCentre d'étude des pathologies respiratoires, INSERM U1100, Faculté de médecine, Université de Tours, Tours, France.
Laetitia Bodet-ContentinMédecine Intensive Réanimation, CHRU de Tours, 2, Bd Tonnellé, 37044, Tours Cedex 9, France.
Valérie GissotCentre d'investigation clinique, INSERM CIC 1415, CHRU de Tours, Tours, France.
Deborah Le PennecCentre d'étude des pathologies respiratoires, INSERM U1100, Faculté de médecine, Université de Tours, Tours, France.
Charlotte Salmon GandonnièreMédecine Intensive Réanimation, CHRU de Tours, 2, Bd Tonnellé, 37044, Tours Cedex 9, France.
Maria CabreraCentre d'étude des pathologies respiratoires, INSERM U1100, Faculté de médecine, Université de Tours, Tours, France.
Pierre-François DequinMédecine Intensive Réanimation, CHRU de Tours, 2, Bd Tonnellé, 37044, Tours Cedex 9, France.
Laurent PlantierCentre d'étude des pathologies respiratoires, INSERM U1100, Faculté de médecine, Université de Tours, Tours, France.
Stephan EhrmannMédecine Intensive Réanimation, CHRU de Tours, 2, Bd Tonnellé, 37044, Tours Cedex 9, France. stephanehrmann@gmail.com.ORCID http://orcid.org/0000-0001-6221-4467
Université de Tours · FRInserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere is an absence of controlled clinical data showing bronchodilation effectiveness after nebulization via nasal high-flow therapy circuits.

resultsTwenty-five patients with reversible airflow obstruction received, in a randomized order: (1) 2.5 mg albuterol delivered via a jet nebulizer with a facial mask; (2) 2.5 mg albuterol delivered via a vibrating mesh nebulizer placed downstream of a nasal high-flow humidification chamber (30 L/min and 37 °C); and (3) nasal high-flow therapy without nebulization. All three conditions induced significant individual increases in forced expiratory volume in one second (FEV

conclusionAlbuterol vibrating mesh nebulization within a nasal high-flow circuit induces similar bronchodilation to standard facial mask jet nebulization. Beyond pharmacological bronchodilation, nasal high flow by itself may induce small but significant bronchodilation.

Indexed as

AlbuterolChronic obstructive pulmonary diseaseNebulizers and vaporizersRespiratory function tests

Identifiers

PMID30570679
PMCPMC6301902
OpenAlexW2905982959

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.