Evidence map›Paper›PMID 30569762›Full record

ArticleCartilage2021

Quality of Cartilage Repair from Marrow Stimulation Correlates with Cell Number, Clonogenic, Chondrogenic, and Matrix Production Potential of Underlying Bone Marrow Stromal Cells in a Rabbit Model.

Garima Dwivedi, Anik Chevrier, Mohamad-Gabriel Alameh, Caroline D Hoemann, Michael D Buschmann

Abstract read
In one paragraph

Article in Cartilage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Garima DwivediChemical Engineering Department, Polytechnique Montreal, Montreal, Quebec, Canada.
Anik ChevrierChemical Engineering Department, Polytechnique Montreal, Montreal, Quebec, Canada.
Mohamad-Gabriel AlamehChemical Engineering Department, Polytechnique Montreal, Montreal, Quebec, Canada.
Caroline D HoemannChemical Engineering Department, Polytechnique Montreal, Montreal, Quebec, Canada.
Michael D BuschmannChemical Engineering Department, Polytechnique Montreal, Montreal, Quebec, Canada.

Funding

CIHR MOP 115186
6 · The paper itself

Abstract

objectivePrevious studies have shown that intrinsic behavior of subchondral bone marrow stem cells (BMSCs) is influenced by donors and locations. To understand the variability in cartilage repair outcomes following bone marrow stimulation, we tested the hypothesis that

methodsFull-thickness cartilage defects were created in the trochlea and condyle in one knee of skeletally mature New Zealand White rabbits (

results

conclusionVariation in cell number, clonogenic, chondrogenic, and matrix production potential of BMSCs correlated with repair response observed

Indexed as

Bone MarrowAnimalsArthroplasty, SubchondralBone and BonesBone MatrixCartilage, ArticularCell CountCells, CulturedChondrogenesisCollagen Type IIDisease Models, AnimalExtracellular Matrix ProteinsHindlimbMesenchymal Stem CellsMesenchymal Stem Cell TransplantationRabbitsCollagen Type IIExtracellular Matrix Proteinsbone marrow stem cellsbone marrow stimulationcartilage repairTGF-βIII

Identifiers

PMID30569762
PMCPMC7970370

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.