ArticleAngewandte Chemie (International ed. in English)2019
Programmed Degradation of Hydrogels with a Double-Locked Domain.
Article in Angewandte Chemie (International ed. in English), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Dual-Wavelength Responsive Hydrogel Glue with Visible-Light Bonding and UV-Triggered Debonding via Ortho-Nitrobenzyl Cleavage.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Synergistic Degradation of Durable Polymer Networks by Light and Acid Enabled by Pyrenylsilicon Crosslinks.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- High-Strength, Antiswelling Directional Layered PVA/MXene Hydrogel for Wearable Devices and Underwater Sensing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The ability to control the degradation of a material is critical to various applications. The purpose of this study was to demonstrate a concept of controlling degradation by using a double-locked domain (DLD). DLDs are molecular structures with two functional units that work cooperatively under environmental stimulation. One unit is triggered to transform without cleavage in the presence of the first stimulus, but this transformation enables the activation of the other unit for cleavage in the presence of the second stimulus. A DLD is presented that is activated to transform through intramolecular reconfiguration when exposed to light. After this transformation, the light-triggered DLD can undergo rapid cleavage under acid treatment. When this DLD is used as the crosslinkers of hydrogels, hydrogels undergo rapid degradation after sequential exposure to light irradiation and acid treatment. Reversing the order of light irradiation and acid treatment or only using individual stimulation does not lead to comparable degradation. Thus, this study has successfully demonstrated the great potential of using DLDs to achieve programmable degradation of materials.
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Registered trials
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