Evidence map›Paper›PMID 30569427›Full record

ArticleJournal of the American Society for Mass Spectrometry2019

DESI Spray Stability in the Negative Ion Mode Is Dependent on Relative Humidity.

Clara L Feider, Rachel J DeHoog, Marta Sans, Jialing Zhang, Anna Krieger, Livia S Eberlin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Society for Mass Spectrometry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Clara L FeiderDepartment of Chemistry, The University of Texas at Austin, 100 E. 24th St. NHB 6.334, Stop A1590, Austin, TX, 78712-1597, USA.
Rachel J DeHoogDepartment of Chemistry, The University of Texas at Austin, 100 E. 24th St. NHB 6.334, Stop A1590, Austin, TX, 78712-1597, USA.
Marta SansDepartment of Chemistry, The University of Texas at Austin, 100 E. 24th St. NHB 6.334, Stop A1590, Austin, TX, 78712-1597, USA.
Jialing ZhangDepartment of Chemistry, The University of Texas at Austin, 100 E. 24th St. NHB 6.334, Stop A1590, Austin, TX, 78712-1597, USA.
Anna KriegerDepartment of Chemistry, The University of Texas at Austin, 100 E. 24th St. NHB 6.334, Stop A1590, Austin, TX, 78712-1597, USA.
Livia S EberlinDepartment of Chemistry, The University of Texas at Austin, 100 E. 24th St. NHB 6.334, Stop A1590, Austin, TX, 78712-1597, USA. liviase@utexas.edu.ORCID http://orcid.org/0000-0002-3885-3215

Funding

Mass Spectrometry Imaging for Clinical Diagnosis and Prognosis of Human CancersR00CA190783 · NCI · UNIVERSITY OF TEXAS AT AUSTIN · PI SCHIAVINATO EBERLIN, LIVIA · 2016 to 2018
$677k
National Cancer Institute R00CA190783NCI NIH HHS R00 CA190783Welch Foundation F-1895
6 · The paper itself

Abstract

Ambient ionization mass spectrometry (MS) techniques, such as desorption electrospray ionization (DESI), have been increasingly used due to their simplicity, minimal sample preparation requirements, and potential applications in the field and the clinic. However, due to their intrinsic nature, the performance of these methods is susceptible to variations in ambient conditions. Here, we present data that suggests DESI-MS analysis becomes inconsistent below a relative humidity (RH) level of ~ 35%. At low RH, we hypothesize that the DESI spray is subjected to frequent electrical discharges, resulting in unstable ionization and atypical mass spectra. Consequentially, poor image quality is observed when used for tissue imaging. Our results suggest that RH control should be considered in DESI-MS experiments to assure data quality. Graphical Abstract ᅟ.

Indexed as

Data qualityDesorption electrospray ionizationHumidityMass spectrometry imaging

Identifiers

PMID30569427
PMCPMC6362844

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.