Evidence map›Paper›PMID 30569308›Full record

ArticleJournal of materials science. Materials in medicine2018

The synthesis and characterization of glutathione-modified superparamagnetic iron oxide nanoparticles and their distribution in rat brains after injection in substantia nigra.

Guihua Han, Baolin Zhang, Hao Zhang, Dong Han, Jie Tan, Boning Yang

Abstract read
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In one paragraph

Article in Journal of materials science. Materials in medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Guihua HanKey Laboratory of Nonferrous and Materials Processing Technology, Ministry of Education; Guangxi Key Laboratory of Optical and Electronic Materials and Devices; College of Materials Science and Engineering, Guilin University of Technology, Jian Gan Road 12, 541004, Guilin, China.
Baolin ZhangKey Laboratory of Nonferrous and Materials Processing Technology, Ministry of Education; Guangxi Key Laboratory of Optical and Electronic Materials and Devices; College of Materials Science and Engineering, Guilin University of Technology, Jian Gan Road 12, 541004, Guilin, China. baolinzhang@ymail.com.ORCID http://orcid.org/0000-0002-2238-3351
Hao ZhangGuangxi Key Laboratory of Brain and Cognitive Neuroscience, Guilin Medical University, 109 North 2nd Huan Cheng Road, 541004, Guilin, China.
Dong HanKey Laboratory of Nonferrous and Materials Processing Technology, Ministry of Education; Guangxi Key Laboratory of Optical and Electronic Materials and Devices; College of Materials Science and Engineering, Guilin University of Technology, Jian Gan Road 12, 541004, Guilin, China.
Jie TanGuangxi Key Laboratory of Brain and Cognitive Neuroscience, Guilin Medical University, 109 North 2nd Huan Cheng Road, 541004, Guilin, China. tanjie@glmc.edu.cn.
Boning YangGuangxi Collaborative Innovation Center for Biomedicine and Department of Human Anatomy, Guangxi Medical University, Shuang Yong Road 22, 530000, Nanning, China. yangbngx@sina.com.

Funding

the National Natural Science Foundation of China 51562007
6 · The paper itself

Abstract

Glutathione-modified superparamagnetic iron oxide nanoparticles (GSH-SPIONs) were prepared by conjugating glutathione (GSH) on the surface of the PEG (Polyethylene glycol)/PEI (polyethyleneimine)-SPIONs which were synthesized by thermal decomposition method. Thermogravimetric analysis showed that the mass fraction of GSH on the surface of SPIONs was 30.64 wt%. GSH-SPIONs in PBS were injected into the substantia nigra of rat brains. The subcellular distributions of the nanoparticles in the brains was examined by the transmission electron microscope (TEM). A remarkable amount of GSH-SPIONs were found in vesicles inside cell bodies and axons, and in mitochondria. TEM pictures show that GSH-SPIONs enter the neuronal cells by endocytosis and travel through axoplasmic transport. GSH-SPIONs have great potential as drug delivery agents in the brain to treat diseases or study brain function via mitochondria-targeting way or axoplasmic transport way.

Indexed as

AnimalsCell SurvivalGlutathioneMagnetite NanoparticlesPC12 CellsRatsSubstantia NigraTissue DistributionGlutathioneMagnetite Nanoparticles

Identifiers

PMID30569308

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.