Evidence map›Paper›PMID 30569292›Full record

ArticleVirologica Sinica2018

Divergent Primary Immune Responses Induced by Human Immunodeficiency Virus-1 gp120 and Hepatitis B Surface Antigen Determine Antibody Recall Responses.

Li Yuan, Wen-Jiang Chen, Jia-Ye Wang, Yan Li, Dan Tian, Ming-Xia Wang, Hao-Tong Yu, Ying-Chu Xu, Di Li, Min Zhuang and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virologica Sinica, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Li YuanDepartment of Microbiology, Harbin Medical University, Harbin, 150081, China.
Wen-Jiang ChenDepartment of Microbiology, Harbin Medical University, Harbin, 150081, China.
Jia-Ye WangDepartment of Microbiology, Harbin Medical University, Harbin, 150081, China.
Yan LiDepartment of Microbiology, Harbin Medical University, Harbin, 150081, China.
Dan TianDepartment of Microbiology, Harbin Medical University, Harbin, 150081, China.
Ming-Xia WangDepartment of Microbiology, Harbin Medical University, Harbin, 150081, China.
Hao-Tong YuDepartment of Microbiology, Harbin Medical University, Harbin, 150081, China.
Ying-Chu XuDepartment of Microbiology, Harbin Medical University, Harbin, 150081, China.
Di LiDepartment of Microbiology, Harbin Medical University, Harbin, 150081, China.
Min ZhuangDepartment of Microbiology, Harbin Medical University, Harbin, 150081, China.
Hong LingDepartment of Microbiology, Harbin Medical University, Harbin, 150081, China. lingh@ems.hrbmu.edu.cn.ORCID http://orcid.org/0000-0002-1886-1242
Harbin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of a vaccine based on human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) that elicits potent protective antibodies against infection has been challenging. Recently, we compared the antibody production patterns of HIV-1 Env gp120 and hepatitis B virus surface antigen (HBsAg) to provide insights into how we may improve the protective efficacy of Env-based immunogens. Our previous study showed that HIV Env and HBsAg display different mechanisms of antibody elicitation and that T cells facilitate the responses to repeated immunizations. Here, to elucidate the detailed roles of primary immunization in immune memory response formation and antibody production, we immunized C57BL/6 mice with each antigen and evaluated the development of T follicular helper (Tfh) cells, germinal centers, and the memory responses involved in prime and boost immunizations. We found that after prime immunization, compared with HBsAg, gp120 induced higher frequencies of Tfh cells and programmed death (PD)-1

Indexed as

Immunologic MemoryAnimalsAntibodies, ViralAntibody FormationB-LymphocytesFemaleGerminal CenterHepatitis B Surface AntigensHIV Envelope Protein gp120ImmunizationImmunization, SecondaryImmunoglobulin GMice, Inbred C57BLProgrammed Cell Death 1 ReceptorTh1 CellsAntibodies, ViralHepatitis B Surface AntigensHIV Envelope Protein gp120Immunoglobulin GPdcd1 protein, mouseProgrammed Cell Death 1 ReceptorHepatitis B surface antigen (HBsAg)Human immunodeficiency virus type 1 envelopeImmune memoryPrimary immune responseProgrammed death-1 (PD-1)

Identifiers

PMID30569292
PMCPMC6335216
OpenAlexW2903868150

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.