ArticleEuropean journal of nuclear medicine and molecular imaging2019
Dual-phase [18F]florbetapir in frontotemporal dementia.
Article in European journal of nuclear medicine and molecular imaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Correlation and Interchangeability of Amyloid, Tau, and Glucose Metabolism PET in Mild Cognitive Impairment and Alzheimer: A Review.Brain sciences · 2025Review
- Aging imaging: the future demand of health management.European journal of nuclear medicine and molecular imaging · 2023Article
- Distinct cerebral cortical perfusion patterns in idiopathic normal-pressure hydrocephalus.Human brain mapping · 2023Article
- [Neurology · 2021Article
- High Correlation of Static First-Minute-Frame (FMF) PET Imaging afterSensors (Basel, Switzerland) · 2021Article
- Evaluation of the early-phase [NeuroImage. Clinical · 2021Article
- PET Parametric Imaging: Past, Present, and Future.IEEE transactions on radiation and plasma medical sciences · 2020Article
- Diagnostic imaging of dementia with Lewy bodies, frontotemporal lobar degeneration, and normal pressure hydrocephalus.Japanese journal of radiology · 2020Review
- Early-phase amyloid PET reproduces metabolic signatures of cognitive decline in Parkinson's disease.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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4 authors.
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Abstract
purposeThe PET tracer [18F]florbetapir is a specific fibrillar amyloid-beta (Aβ) biomarker. During the late scan phase (> 40 min), it provides pathological information about Aβ status. Early scan phase (0-10 min) can provide FDG-'like' information. The current investigation tested the feasibility of using florbetapir as a dual-phase biomarker in behavioural variant frontotemporal dementia (bvFTD).
methodsEight bvFTD patients underwent [18F]florbetapir and [18]FDG-PET scans. Additionally, ten healthy controls and ten AD patients underwent florbetapir-PET only. PET data were acquired dynamically for 60-min post-injection. The bvFTD PET data were used to define an optimal time window, representing blood flow-related pseudo-metabolism ('pseudo-FDG'), of florbetapir data that maximally correlated with the corresponding real FDG SUVR (40-60 min) in a composite neocortical FTD region.
resultsA 2 to 5-min time window post-injection of the florbetapir-PET data provided the largest correlation (Pearson's r = 0.79, p = 0.02) to the FDG data. The pseudo-FDG images demonstrated strong internal consistency with actual FDG data and were also visually consistent with the bvFTD patients' hypometabolic profiles. The ability to identify bvFTD from blind visual rating of pseudo-FDG images was consistent with previous reports using FDG data (sensitivity = 75%, specificity = 85%).
conclusionsThis investigation demonstrates that early phase florbetapir uptake shows a reduction of frontal lobe perfusion in bvFTD, similar to metabolic findings with FDG. Thus, dynamic florbetapir scans can serve as a dual-phase biomarker in dementia patients to distinguish FTD from AD and cognitively normal elderly, removing the need for a separate FDG-PET scan in challenging dementia cases.
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