ArticleInternational journal of molecular medicine2019
Construction of a long non‑coding RNA-mediated competitive endogenous RNA network reveals global patterns and regulatory markers in gestational diabetes.
Article in International journal of molecular medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 18 citations in OpenAlex.
- lncRNA PANDAR predicts adverse pregnancy outcomes and reflects hyperglycemia-associated cellular stress in gestational diabetes mellitus.Journal of endocrinological investigation · 2026Article
- Diagnostic and prognostic significance of lncRNA THRIL in gestational diabetes mellitus and the regulation of trophoblastic function.Irish journal of medical science · 2025Article
- LncRNA HCG27 Promotes Glucose Uptake Ability of HUVECs by MiR-378a-3p/MAPK1 Pathway.Current medical science · 2023Article
- The role of noncoding RNA and its diagnostic potential in intrahepatic cholestasis of pregnancy: a research update.Frontiers in genetics · 2023Review
- Non-Coding RNAs Regulate Spontaneous Abortion: A Global Network and System Perspective.International journal of molecular sciences · 2022Review
- Dominant Myocardial Fibrosis and Complex Immune Microenvironment Jointly Shape the Pathogenesis of Arrhythmogenic Right Ventricular Cardiomyopathy.Frontiers in cardiovascular medicine · 2022Article
- Construction of lncRNA-related competing endogenous RNA network and identification of hub genes in recurrent implantation failure.Reproductive biology and endocrinology : RB&E · 2021Article
- LncRNA XIST serves as a diagnostic biomarker in gestational diabetes mellitus and its regulatory effect on trophoblast cell via miR-497-5p/FOXO1 axis.Cardiovascular diagnosis and therapy · 2021Article
- Diagnostic value of candidate noncoding RNAs in leukocytes of patients with gestational diabetes mellitus.Experimental and therapeutic medicine · 2021Article
- Transcriptomic Profiling of Human Placenta in Gestational Diabetes Mellitus at the Single-Cell Level.Frontiers in endocrinology · 2021Article
- Identification of Key Molecules and lncRNA-miRNA-mRNA ceRNA Network in Preeclampsia.International journal of general medicine · 2021Article
- Identification of inflammation‑associated circulating long non‑coding RNAs and genes in intracranial aneurysm rupture‑induced subarachnoid hemorrhage.Molecular medicine reports · 2020Article
- Whole transcriptome expression profiles in placenta samples from women with gestational diabetes mellitus.Journal of diabetes investigation · 2020Article
- [Long non-coding RNAs show different expression profiles and display competing endogenous RNA potential in placenta accreta spectrum disorders].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2019Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gestational diabetes mellitus (GDM) is a common disease affecting pregnant women. Recent studies have suggested that competing endogenous RNAs (ceRNAs), which compete with long non‑coding RNAs (lncRNAs) for microRNA (miRNA or miR) binding and indirectly regulate miRNA targets through competing interactions, play a critical role in disease. In this study, we present a computationally integrated approach with which to construct a lncRNA‑mediated ceRNA network (LCEN) in GDM by integrating RNA interactions and expression data. lncRNAs exhibited specific features and played critical roles in GDM‑associated LCEN. The construction of a global functional score profile revealed that ceRNAs had a high activity in GDM. We extracted several ceRNA modules and demonstrated that these modules had increased close interactions. We further discovered that these ceRNA modules may be utilized as specific and effective circulating biomarkers for GDM. Finally, functional analyses demonstrated that the GDM‑associated ceRNAs participated in the regulation of irisin and the thyroid hormone signaling pathway. It was suggested that there were close associations between the thyroid hormone and GDM. Collectively, ceRNAs may accelerate biomarker discovery and therapeutic development in GDM.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.