ArticleThe journal of nutrition, health & aging2019
Association of BNP with Frailty in Elderly Population: Rugao Longevity and Ageing Study.
Article in The journal of nutrition, health & aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Association between natriuretic peptides and C-reactive protein with frailty in heart failure: a systematic review and meta-analysis.Aging clinical and experimental research · 2024Pooled it
- Prevalence and risk factors of frailty in older patients with chronic heart failure: a systematic review and meta-analysis.Aging clinical and experimental research · 2023Pooled it
- Functional, molecular, and digital measurements of biological age.The Journal of clinical investigation · 2026Review
- Associations between cognitive frailty and circulating cardiovascular biomarkers in a memory clinic cohort.GeroScience · 2026Article
- Biomarkers and Clinical Evaluation in the Detection of Frailty.International journal of molecular sciences · 2025Review
- Improvement of Physical Functions in Elderly Patients with Heart Failure Depends on the Hepatic Reserve.Physical therapy research · 2025Article
- Association of metformin exposure with low risks of frailty and adverse outcomes in patients with diabetes.European journal of medical research · 2023Article
- Causal Association of Cardiac Function by Magnetic Resonance Imaging with Frailty Index: A Mendelian Randomization Study.Phenomics (Cham, Switzerland) · 2022Article
- Clinical frailty assessment might be associated with mortality in incident dialysis patients.Scientific reports · 2022Article
- Associations between inflammation, coagulation, cardiac strain and injury, and subclinical vascular disease with frailty in older men: a cross-sectional study.BMC geriatrics · 2022Article
- Associations between inflammation, cardiovascular biomarkers and incident frailty: the British Regional Heart Study.Age and ageing · 2021Article
- The association of proBNPage with manifestations of age-related cardiovascular, physical, and psychological impairment in community-dwelling older adults.GeroScience · 2021Article
- Plasma N-Terminal Pro-B-Type Natriuretic Peptide Is Associated with Intrinsic Capacity Decline in an Older Population.The journal of nutrition, health & aging · 2021Article
- Associations of TNF-α -308 G>A and TNF-β 252 A>G with Physical Function and BNP-Rugao Longevity and Ageing Study.The journal of nutrition, health & aging · 2020Article
- Cardiovascular Health in Individuals with Exceptional Longevity Residing in Arkansas.Gerontology & geriatric medicineArticle
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo explore the associations of B-type natriuretic peptide (BNP) with physical frailty status as well as each domain of frailty in a general elderly population.
designCross-sectional analysis of prospective cohort study.
settingAll of 31 communities in Jiang'an township.
participantsOverall 1338 participants (aged 70-89 years, mean 77.42±4.08 years) without a history of cardiovascular diseases in the third-wave of the aging arm of the Rugao Longevity and Aging Study (RuLAS). MEASUREMENTS: Frailty was defined as the presence of ≥3 domains among five modified Fried's criteria (unintentional weight loss, low physical activity level, weakness (low grip strength), exhaustion, and slowness (slow gait speed)) and pre-frailty as the presence of 1-2 domains.
resultsThe prevalence of frailty and pre-frailty was 10.4% and 53.3%, respectively, in this elderly population. Elevated BNP (≥100 pg/mL) was significantly associated with pre-frailty (OR: 1.61, 95% CI: 1.13-2.29) and frailty (OR: 2.63, 95% CI: 1.61-4.32) after adjustment for covariates. In addition, elevated BNP was associated with low grip strength (OR: 2.00, 95% CI: 1.41-2.82) and low gait speed (OR: 1.62, 95% CI: 1.15-2.28) after adjustment for multiple covariates. Log BNP was inversely associated with grip strength (r= -0.265, p<0.001) and gait speed (r= -0.189, p<0.001).
conclusionElevated plasma BNP was associated with increased risks of frailty, pre-frailty, and low levels of grip strength and gait speed in the elderly community people.
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