Evidence map›Paper›PMID 30569018›Full record

ArticleJournal of scleroderma and related disorders2017

Defining Skin Ulcers in Systemic Sclerosis: Systematic Literature Review and Proposed World Scleroderma Foundation (WSF) definition.

Y A Suliman, C Bruni, S R Johnson, E Praino, M Alemam, N Borazan, L Cometi, B Meyers, D Khanna, Y Allanore and 9 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of scleroderma and related disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 12 institutions in 8 countries.

Y A Suliman *Division of Rheumatology, David Geffen School of Medicine, University of California Los Angeles, 1000 Veterans Avenue, Los Angeles, California 90025, USA.
C Bruni *Dept Clinical & Experimental Medicine, University and Division of Rheumatology & Scleroderma Unit, AOUC, University of Florence, Florence,Italy.
S R JohnsonToronto Scleroderma Program, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.
E PrainoDept Clinical & Experimental Medicine, University and Division of Rheumatology & Scleroderma Unit, AOUC, University of Florence, Florence,Italy.
M AlemamClinical pathology department, South valley university, Qena, Egypt.
N BorazanDivision of Rheumatology, David Geffen School of Medicine, University of California Los Angeles, 1000 Veterans Avenue, Los Angeles, California 90025, USA.
L CometiDept Clinical & Experimental Medicine, University and Division of Rheumatology & Scleroderma Unit, AOUC, University of Florence, Florence,Italy.
B MeyersLouise M. Darling Biomedical Library, University of California, Los Angeles, USA.
D KhannaUniversity of Michigan, Ann Arbor, USA.
Y AllanoreParis Descartes University and Cochin Hospital, AP-HP, Paris, France.
M BaronJewish General Hospital and McGill University, Montreal, Quebec, Canada.
T KriegDepartment of Dermatology, University of Cologne, Cologne, Germany; Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.
A HerrickUniversity of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
A AfonsoUniversity of Oporto, Portugal.
O DistlerDivision of Rheumatology, University Hospital Zurich, Switzerland.
S KafajaDivision of Rheumatology, David Geffen School of Medicine, University of California Los Angeles, 1000 Veterans Avenue, Los Angeles, California 90025, USA.
C P DentonCentre for Rheumatology, Royal Free Hospital, London, UK.
M Matucci-CerinicDept Clinical & Experimental Medicine, University and Division of Rheumatology & Scleroderma Unit, AOUC, University of Florence, Florence,Italy.
D E FurstDivision of Rheumatology, David Geffen School of Medicine, University of California Los Angeles, 1000 Veterans Avenue, Los Angeles, California 90025, USA.
University of California, Los Angeles · USUniversity of Florence · ITDélégation Paris 5 · FRJewish General Hospital · CASouth Valley University · EGThe Royal Free Hospital · GBUniversity Hospital of Zurich · CHUniversity of Bari Aldo Moro · ITUniversity of Cologne · DEUniversity of Manchester · GBUniversity of Michigan–Ann Arbor · USUniversity of Toronto · CA

Funding

Outcomes Research in Rheumatic DiseasesK24AR063120 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KHANNA, DINESH · 2012 to 2022
$1.6M
NIAMS NIH HHS K24 AR063120
6 · The paper itself

Abstract

purposeThere is a lack of a valid, definition for skin ulcers in SSc to be used in clinical trials. Our aim was to develop a consensus definition for SSc-skin ulcers based on the results of a systematic literature review (SLR) for skin ulcer definitions and expert opinion; and to evaluate its face validity, reliability and feasibility.

methodsSLR for skin ulcer definitions was conducted using PubMed, Web of Science, and Cochrane library for articles published from inception to January 1

resultsA total of 3464 abstracts and titles were screened, and 446 articles were fully evaluated. Of these, 66 met eligibility criteria and skin ulcer definitions were extracted. SSc experts discussed, refined and voted on the consensus definition using nominal process. Kappa for inter-, intra-rater rater agreement was 0.51, 0.90 respectively. The mean time to decide if the lesion is an ulcer was 7.4 sec. All investigators endorsed the face validity of the new definition in the CRFs.

conclusionUsing a SLR and a nominal technique, we developed a preliminary consensus-based definition of SSc-skin ulcers. Face validity, feasibility and reliability were demonstrated for the developed definition.

Indexed as

amputationdigital lossgangreneskin ulcerssystemic sclerosis

Identifiers

PMID30569018
PMCPMC6296474
OpenAlexW2614361030

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.